Controlled pH Stability and Adjustable Cellular Uptake of Mixed-Charge Nanoparticles

Nanoparticles functionalized with mixed self-assembled monolayers (m-SAMs) comprising positively and negatively charged thiols are stable at both low and high pH but precipitate sharply at the pH where the charges on the particle are balanced (pHprec). By adjusting the proportion of the positively a...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2013-05, Vol.135 (17), p.6392-6395
Main Authors: Pillai, Pramod P, Huda, Sabil, Kowalczyk, Bartlomiej, Grzybowski, Bartosz A
Format: Article
Language:English
Subjects:
Amines - chemistry
Animals
Cell Line
Drug Stability
Electrochemistry
Fibroblasts - metabolism
Gold - chemistry
Hydrogen-Ion Concentration
Indicators and Reagents
Ligands
Nanoparticles - chemistry
Particle Size
Rats
Solubility
Spectrophotometry, Ultraviolet
Sulfhydryl Compounds - chemistry
Surface-Active Agents
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Summary:Nanoparticles functionalized with mixed self-assembled monolayers (m-SAMs) comprising positively and negatively charged thiols are stable at both low and high pH but precipitate sharply at the pH where the charges on the particle are balanced (pHprec). By adjusting the proportion of the positively and negatively charged ligands in the m-SAM or changing particle size, pHprec can be varied flexibly between ∼4 and ∼7. In addition, changes in the SAMs’ composition and particles’ net charge translate into different degrees of cellular uptake. Remarkably, the presence of the positively charged thiols allows for the uptake of particles having net negative charge.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja4001272