Hepatitis B virus infection is associated with deletion of chromosome 8p in multiple myeloma

Serological analyses within epidemiological cohort and case‐control studies indicate to an association between HBV infection and risk of multiple myeloma (MM). To verify the relationship with an independent approach, we investigated the correlation between HBV positivity and chromosomal aberrations...

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Bibliographic Details
Published in:European journal of haematology 2013-04, Vol.90 (4), p.279-285
Main Authors: Becker, Nikolaus, Byl, Anne, Friedrich, Susanne, Jauch, Anna, Schnitzler, Paul, Egerer, Gerlinde, Ho, Anthony D, Goldschmidt, Hartmut, Neben, Kai
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - genetics
chromosomal aberrations
Chromosome Aberrations
Chromosome Deletion
Chromosome Disorders - genetics
Chromosomes, Human, Pair 13 - genetics
Chromosomes, Human, Pair 8 - genetics
Female
Genetic Association Studies
Germany
HBV
Hepatitis B - complications
Hepatitis B - genetics
Hepatitis B - immunology
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - pathogenicity
Humans
Liver Neoplasms - complications
Liver Neoplasms - genetics
lymphoma
Male
Middle Aged
Multiple Myeloma - complications
Multiple Myeloma - etiology
Multiple Myeloma - genetics
non-Hodgkin lymphoma
Odds Ratio
Registries
Virus Integration - genetics
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Summary:Serological analyses within epidemiological cohort and case‐control studies indicate to an association between HBV infection and risk of multiple myeloma (MM). To verify the relationship with an independent approach, we investigated the correlation between HBV positivity and chromosomal aberrations within 680 patients of the National Center for Tumor Diseases Heidelberg for which the serological HBV status (HBsAg and anti‐HBc) and FISH data for five gains (1q21, 9q34, 11q23, 15q22, 19q13), five losses (6q21, 8p21, 13q14, 17p13, 22q11), and three IgH translocations [t(4,14), t(11,14), t(14,16)] were available. Deletion of 8p21 and 13q14 were shown associated with HBV positivity within hepatocellular carcinoma in other investigations. In the present evaluation, the odds ratio for loss of 8p21 was significantly elevated (OR = 2.74, 95% CL = 1.36–5.50, P = 0.0048) and for loss of 13q14 non‐significantly increased (OR = 1.40, 95% CL = 0.74–2.65) in anti‐HBc positive patients. The results provide further support for a role of HBV infection in the pathogenesis of MM.
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.12018