Chromatin Movement in the Maintenance of Genome Stability

Mechanistic analyses based on improved imaging techniques have begun to explore the biological implications of chromatin movement within the nucleus. Studies in both prokaryotes and eukaryotes have shed light on what regulates the mobility of DNA over long distances. Interestingly, in eukaryotes, ge...

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Bibliographic Details
Published in:Cell 2013-03, Vol.152 (6), p.1355-1364
Main Authors: Dion, Vincent, Gasser, Susan M.
Format: Article
Language:English
Subjects:
Animals
chromatin
Chromatin - chemistry
Chromatin - metabolism
DNA
DNA - metabolism
DNA Damage
DNA Repair
eukaryotic cells
genome
Genomic Instability
Humans
image analysis
loci
Movement
prokaryotic cells
Transcription, Genetic
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Summary:Mechanistic analyses based on improved imaging techniques have begun to explore the biological implications of chromatin movement within the nucleus. Studies in both prokaryotes and eukaryotes have shed light on what regulates the mobility of DNA over long distances. Interestingly, in eukaryotes, genomic loci increase their movement in response to double-strand break induction. Break mobility, in turn, correlates with the efficiency of repair by homologous recombination. We review here the source and regulation of DNA mobility and discuss how it can both contribute to and jeopardize genome stability.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2013.02.010