Comparison of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis adhesive properties and pathogenicity

Retrospective studies indicate that Candida metapsilosis and Candida orthopsilosis each represents 1–10% of the infections/colonisations attributed to C. parapsilosis by conventional biochemical tests. Little is known on the virulence properties of these fungi and on their role in the establishment/...

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Bibliographic Details
Published in:International journal of medical microbiology 2013-03, Vol.303 (2), p.98-103
Main Authors: Bertini, Alessia, De Bernardis, Flavia, Hensgens, Lambert A.M., Sandini, Silvia, Senesi, Sonia, Tavanti, Arianna
Format: Article
Language:English
Subjects:
Adhesion
Animals
Candida
Candida - enzymology
Candida - pathogenicity
Candida - physiology
Candida metapsilosis
Candida orthopsilosis
Candida parapsilosis
Candidiasis, Vulvovaginal - microbiology
Candidiasis, Vulvovaginal - pathology
Cell Adhesion
Cells, Cultured
Colony Count, Microbial
Disease Models, Animal
Ectophosphatase
Epithelial Cells - microbiology
Female
Humans
Male
Mice
Mice, Inbred BALB C
Murine vaginitis
Phosphoric Monoester Hydrolases - secretion
Vagina - microbiology
Virulence
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Summary:Retrospective studies indicate that Candida metapsilosis and Candida orthopsilosis each represents 1–10% of the infections/colonisations attributed to C. parapsilosis by conventional biochemical tests. Little is known on the virulence properties of these fungi and on their role in the establishment/progression of the infection. In this study, the adhesive properties of clinical isolates belonging to the ‘psilosis’ species were assessed in an in vitro model of co-incubation with human buccal epithelial cells (HBECs). Ectophosphatase activity was also measured for all isolates, since the activity of this enzyme has previously been linked to adhesion properties in C. parapsilosis. The results indicate that whilst C. parapsilosis and C. orthopsilosis strains showed similar adhesion abilities, C. metapsilosis isolates displayed a significantly lower ability to adhere to HBECs (P
ISSN:1438-4221
1618-0607
DOI:10.1016/j.ijmm.2012.12.006