Pathological and Aetiological Studies in Sheep Exhibiting Extrathoracic Metastasis of Ovine Pulmonary Adenocarcinoma (Jaagsiekte)

Seven sheep with a histopathological diagnosis of pulmonary adenocarcinoma with extrathoracic metastases were included in this retrospective study aiming to describe the pathological findings and to establish their relationship with Jaagsiekte sheep retrovirus (JSRV). In order of frequency, extratho...

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Bibliographic Details
Published in:Journal of comparative pathology 2013-02, Vol.148 (2-3), p.139-147
Main Authors: Minguijón, E., González, L., De las Heras, M., Gómez, N., García-Goti, M., Juste, R.A., Moreno, B.
Format: Article
Language:English
Subjects:
adrenal glands
Animals
chest
diaphragm
digestive tract
Female
heart
histopathology
immunohistochemistry
Jaagsiekte sheep retrovirus
Jaagsiekte sheep retrovirus - isolation & purification
Jaagsiekte sheep retrovirus - pathogenicity
Kidney - pathology
Kidney - virology
Kidney Neoplasms - secondary
Kidney Neoplasms - veterinary
Kidney Neoplasms - virology
kidneys
liver
Liver Neoplasms - secondary
Liver Neoplasms - veterinary
Liver Neoplasms - virology
Lung - pathology
Lung - virology
lymph nodes
Male
metastases
metastasis
Muscle Neoplasms - secondary
Muscle Neoplasms - veterinary
Muscle Neoplasms - virology
Muscle, Skeletal - pathology
Muscle, Skeletal - virology
nucleic acids
ovine pulmonary adenocarcinoma
ovine pulmonary adenomatosis
polymerase chain reaction
Pulmonary Adenomatosis, Ovine - pathology
Pulmonary Adenomatosis, Ovine - virology
Retrospective Studies
Sheep
Sheep Diseases - pathology
Sheep Diseases - virology
skeletal muscle
spleen
Spleen - pathology
Spleen - virology
Splenic Neoplasms - secondary
Splenic Neoplasms - veterinary
Splenic Neoplasms - virology
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Description
Summary:Seven sheep with a histopathological diagnosis of pulmonary adenocarcinoma with extrathoracic metastases were included in this retrospective study aiming to describe the pathological findings and to establish their relationship with Jaagsiekte sheep retrovirus (JSRV). In order of frequency, extrathoracic metastases were found in the liver, kidneys, skeletal muscle, digestive tract, spleen, skin and adrenal glands. Intrathoracic metastases involved the chest wall, regional lymph nodes, diaphragm and heart. Immunohistochemistry and polymerase chain reaction allowed detection of JSRV-related protein and nucleic acid, respectively, in the extrathoracic tumours of all cases. It is concluded that extrathoracic metastases constitute a pathological event of ovine pulmonary adenocarcinoma and confirm the malignant character of this virus-induced neoplasia.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2012.06.003