Olfactory bulb volume in patients with temporal lobe epilepsy

The study aimed to investigate the volume of the olfactory bulb (OB) in patients with temporal lobe epilepsy (TLE). Specifically, we wanted to see whether the olfactory deficit typically found in TLE patients also exerts a top-down influence on the OB. Twenty patients, and 20 age- and sex-matched he...

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Bibliographic Details
Published in:Journal of neurology 2013-04, Vol.260 (4), p.1004-1008
Main Authors: Hummel, Thomas, Henkel, Sophia, Negoias, Simona, Galván, José R. B., Bogdanov, Vasyl, Hopp, Peter, Hallmeyer-Elgner, Susanne, Gerber, Johannes, Reuner, Ulrike, Haehner, Antje
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Electroencephalography
Epilepsy
Epilepsy, Temporal Lobe - complications
Epilepsy, Temporal Lobe - pathology
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neuroradiology
Neurosciences
Odorants
Olfaction Disorders - diagnosis
Olfaction Disorders - etiology
Olfactory Bulb - pathology
Organ Size
Original Communication
Psychophysics
Smell - physiology
Young Adult
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Summary:The study aimed to investigate the volume of the olfactory bulb (OB) in patients with temporal lobe epilepsy (TLE). Specifically, we wanted to see whether the olfactory deficit typically found in TLE patients also exerts a top-down influence on the OB. Twenty patients, and 20 age- and sex-matched healthy controls underwent olfactory testing by means of the Sniffin′ Sticks testing device (measurement of odor threshold, and identification abilities). In addition, they underwent an MR scan with 2-mm-thick T2-weighted fast spin-echo images without interslice gap in the coronal plane covering the anterior and middle segments of the base of the skull. Olfactory function was significantly impaired in TLE patients compared to healthy controls both at threshold level and for odor identification ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-012-6741-x