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Olfactory bulb volume in patients with temporal lobe epilepsy
The study aimed to investigate the volume of the olfactory bulb (OB) in patients with temporal lobe epilepsy (TLE). Specifically, we wanted to see whether the olfactory deficit typically found in TLE patients also exerts a top-down influence on the OB. Twenty patients, and 20 age- and sex-matched he...
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| Published in: | Journal of neurology 2013-04, Vol.260 (4), p.1004-1008 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 1008 |
| container_issue | 4 |
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| container_title | Journal of neurology |
| container_volume | 260 |
| creator | Hummel, Thomas Henkel, Sophia Negoias, Simona Galván, José R. B. Bogdanov, Vasyl Hopp, Peter Hallmeyer-Elgner, Susanne Gerber, Johannes Reuner, Ulrike Haehner, Antje |
| description | The study aimed to investigate the volume of the olfactory bulb (OB) in patients with temporal lobe epilepsy (TLE). Specifically, we wanted to see whether the olfactory deficit typically found in TLE patients also exerts a top-down influence on the OB. Twenty patients, and 20 age- and sex-matched healthy controls underwent olfactory testing by means of the Sniffin′ Sticks testing device (measurement of odor threshold, and identification abilities). In addition, they underwent an MR scan with 2-mm-thick T2-weighted fast spin-echo images without interslice gap in the coronal plane covering the anterior and middle segments of the base of the skull. Olfactory function was significantly impaired in TLE patients compared to healthy controls both at threshold level and for odor identification (
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| doi_str_mv | 10.1007/s00415-012-6741-x |
| format | article |
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p
< 0.001); in addition, OB volumes were smaller than in controls (
p
= 0.013). The deficit seen at the level of the OB did not correlate with the side of the epileptic focus. Assuming that the olfactory deficit in TLE patients is due to the central nervous epileptic focus it appears that the OB volume is not only subject to changes in the periphery of the olfactory system, but also changes as a consequence to changes at a cortical level.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-012-6741-x</identifier><identifier>PMID: 23135292</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Case-Control Studies ; Electroencephalography ; Epilepsy ; Epilepsy, Temporal Lobe - complications ; Epilepsy, Temporal Lobe - pathology ; Female ; Functional Laterality ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurology ; Neuroradiology ; Neurosciences ; Odorants ; Olfaction Disorders - diagnosis ; Olfaction Disorders - etiology ; Olfactory Bulb - pathology ; Organ Size ; Original Communication ; Psychophysics ; Smell - physiology ; Young Adult</subject><ispartof>Journal of neurology, 2013-04, Vol.260 (4), p.1004-1008</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-6ee968a23f8a1d1207b709861e7bd11d873fd8cfea15279a0d525a380ff16f573</citedby><cites>FETCH-LOGICAL-c405t-6ee968a23f8a1d1207b709861e7bd11d873fd8cfea15279a0d525a380ff16f573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23135292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hummel, Thomas</creatorcontrib><creatorcontrib>Henkel, Sophia</creatorcontrib><creatorcontrib>Negoias, Simona</creatorcontrib><creatorcontrib>Galván, José R. B.</creatorcontrib><creatorcontrib>Bogdanov, Vasyl</creatorcontrib><creatorcontrib>Hopp, Peter</creatorcontrib><creatorcontrib>Hallmeyer-Elgner, Susanne</creatorcontrib><creatorcontrib>Gerber, Johannes</creatorcontrib><creatorcontrib>Reuner, Ulrike</creatorcontrib><creatorcontrib>Haehner, Antje</creatorcontrib><title>Olfactory bulb volume in patients with temporal lobe epilepsy</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>The study aimed to investigate the volume of the olfactory bulb (OB) in patients with temporal lobe epilepsy (TLE). Specifically, we wanted to see whether the olfactory deficit typically found in TLE patients also exerts a top-down influence on the OB. Twenty patients, and 20 age- and sex-matched healthy controls underwent olfactory testing by means of the Sniffin′ Sticks testing device (measurement of odor threshold, and identification abilities). In addition, they underwent an MR scan with 2-mm-thick T2-weighted fast spin-echo images without interslice gap in the coronal plane covering the anterior and middle segments of the base of the skull. Olfactory function was significantly impaired in TLE patients compared to healthy controls both at threshold level and for odor identification (
p
< 0.001); in addition, OB volumes were smaller than in controls (
p
= 0.013). The deficit seen at the level of the OB did not correlate with the side of the epileptic focus. Assuming that the olfactory deficit in TLE patients is due to the central nervous epileptic focus it appears that the OB volume is not only subject to changes in the periphery of the olfactory system, but also changes as a consequence to changes at a cortical level.</description><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Electroencephalography</subject><subject>Epilepsy</subject><subject>Epilepsy, Temporal Lobe - complications</subject><subject>Epilepsy, Temporal Lobe - pathology</subject><subject>Female</subject><subject>Functional Laterality</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Odorants</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Olfaction Disorders - etiology</subject><subject>Olfactory Bulb - pathology</subject><subject>Organ Size</subject><subject>Original Communication</subject><subject>Psychophysics</subject><subject>Smell - physiology</subject><subject>Young Adult</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkUtP3TAQha2qqPfy-AFsUKRuukmZ8SNxFl1UqNBKSGxgbTnJGHLlPGonhfvvMVxAVaVKrGZxvnNGM4exY4SvCFCeRgCJKgfkeVFKzB8-sDVKwXOUqvrI1iAk5EoouWL7MW4AQCfhE1txgULxiq_ZtyvvbDOPYZvVi6-zP6Nfesq6IZvs3NEwx-y-m--ymfppDNZnfqwpo6nzNMXtIdtz1kc6epkH7Ob8x_XZz_zy6uLX2ffLvJGg5rwgqgptuXDaYoscyrqEShdIZd0itroUrtWNI4uKl5WFVnFlhQbnsHCqFAfsyy53CuPvheJs-i425L0daFyiQSG11Kqq-DtQLkWFQqiEfv4H3YxLGNIhzxRgepJIFO6oJowxBnJmCl1vw9YgmKcazK4Gk2owTzWYh-Q5eUle6p7aN8fr3xPAd0BM0nBL4a_V_019BDjGkQc</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Hummel, Thomas</creator><creator>Henkel, Sophia</creator><creator>Negoias, Simona</creator><creator>Galván, José R. B.</creator><creator>Bogdanov, Vasyl</creator><creator>Hopp, Peter</creator><creator>Hallmeyer-Elgner, Susanne</creator><creator>Gerber, Johannes</creator><creator>Reuner, Ulrike</creator><creator>Haehner, Antje</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130401</creationdate><title>Olfactory bulb volume in patients with temporal lobe epilepsy</title><author>Hummel, Thomas ; Henkel, Sophia ; Negoias, Simona ; Galván, José R. B. ; Bogdanov, Vasyl ; Hopp, Peter ; Hallmeyer-Elgner, Susanne ; Gerber, Johannes ; Reuner, Ulrike ; Haehner, Antje</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-6ee968a23f8a1d1207b709861e7bd11d873fd8cfea15279a0d525a380ff16f573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Electroencephalography</topic><topic>Epilepsy</topic><topic>Epilepsy, Temporal Lobe - complications</topic><topic>Epilepsy, Temporal Lobe - pathology</topic><topic>Female</topic><topic>Functional Laterality</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Odorants</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Olfaction Disorders - etiology</topic><topic>Olfactory Bulb - pathology</topic><topic>Organ Size</topic><topic>Original Communication</topic><topic>Psychophysics</topic><topic>Smell - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hummel, Thomas</creatorcontrib><creatorcontrib>Henkel, Sophia</creatorcontrib><creatorcontrib>Negoias, Simona</creatorcontrib><creatorcontrib>Galván, José R. B.</creatorcontrib><creatorcontrib>Bogdanov, Vasyl</creatorcontrib><creatorcontrib>Hopp, Peter</creatorcontrib><creatorcontrib>Hallmeyer-Elgner, Susanne</creatorcontrib><creatorcontrib>Gerber, Johannes</creatorcontrib><creatorcontrib>Reuner, Ulrike</creatorcontrib><creatorcontrib>Haehner, Antje</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hummel, Thomas</au><au>Henkel, Sophia</au><au>Negoias, Simona</au><au>Galván, José R. B.</au><au>Bogdanov, Vasyl</au><au>Hopp, Peter</au><au>Hallmeyer-Elgner, Susanne</au><au>Gerber, Johannes</au><au>Reuner, Ulrike</au><au>Haehner, Antje</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Olfactory bulb volume in patients with temporal lobe epilepsy</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>260</volume><issue>4</issue><spage>1004</spage><epage>1008</epage><pages>1004-1008</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>The study aimed to investigate the volume of the olfactory bulb (OB) in patients with temporal lobe epilepsy (TLE). Specifically, we wanted to see whether the olfactory deficit typically found in TLE patients also exerts a top-down influence on the OB. Twenty patients, and 20 age- and sex-matched healthy controls underwent olfactory testing by means of the Sniffin′ Sticks testing device (measurement of odor threshold, and identification abilities). In addition, they underwent an MR scan with 2-mm-thick T2-weighted fast spin-echo images without interslice gap in the coronal plane covering the anterior and middle segments of the base of the skull. Olfactory function was significantly impaired in TLE patients compared to healthy controls both at threshold level and for odor identification (
p
< 0.001); in addition, OB volumes were smaller than in controls (
p
= 0.013). The deficit seen at the level of the OB did not correlate with the side of the epileptic focus. Assuming that the olfactory deficit in TLE patients is due to the central nervous epileptic focus it appears that the OB volume is not only subject to changes in the periphery of the olfactory system, but also changes as a consequence to changes at a cortical level.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23135292</pmid><doi>10.1007/s00415-012-6741-x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Case-Control Studies Electroencephalography Epilepsy Epilepsy, Temporal Lobe - complications Epilepsy, Temporal Lobe - pathology Female Functional Laterality Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medicine Medicine & Public Health Middle Aged Neurology Neuroradiology Neurosciences Odorants Olfaction Disorders - diagnosis Olfaction Disorders - etiology Olfactory Bulb - pathology Organ Size Original Communication Psychophysics Smell - physiology Young Adult |
| title | Olfactory bulb volume in patients with temporal lobe epilepsy |
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