Effectiveness of an influenza A (H1N1) 2009 monovalent vaccine among Japanese pregnant women: A prospective observational study assessing antibody efficacy

Highlights ► Effectiveness of an influenza A (H1N1) 2009 monovalent vaccine was estimated. ► We prospectively observed 135 Japanese pregnant women. ► Vaccine effectiveness was calculated using an index of “antibody efficacy”. ► Antibody efficacy was 91% among subjects in the first or second trimeste...

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Bibliographic Details
Published in:Vaccine 2012-12, Vol.30 (52), p.7630-7636
Main Authors: Fukushima, Wakaba, Ohfuji, Satoko, Deguchi, Masaaki, Kawabata, Kazume, Hatayama, Hideaki, Yoshida, Hideki, Maeda, Akiko, Hirota, Yoshio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergy and Immunology
Antibodies, Viral - blood
Antibody efficacy
Asian Continental Ancestry Group
Effectiveness
Female
hemagglutination
Hemagglutination Inhibition Tests
Humans
Influenza
Influenza A Virus, H1N1 Subtype - immunology
Influenza vaccine
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Influenza, Human - virology
Observational studies
Pandemic influenza
Pandemics
Pregnancy
Pregnant Women
Prospective Studies
recruitment
Vaccines
Womens health
Young Adult
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Summary:Highlights ► Effectiveness of an influenza A (H1N1) 2009 monovalent vaccine was estimated. ► We prospectively observed 135 Japanese pregnant women. ► Vaccine effectiveness was calculated using an index of “antibody efficacy”. ► Antibody efficacy was 91% among subjects in the first or second trimester at recruitment. ► The corresponding vaccine effectiveness was estimated to be 79%.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.10.027