Changes in the composition of the pneumococcal population and in IPD incidence in The Netherlands after the implementation of the 7-valent pneumococcal conjugate vaccine

Abstract The implementation of nationwide pneumococcal vaccination may lead to alterations in the pneumococcal population due to selective pressure induced by the vaccine. To monitor such changes, pneumococcal isolates causing invasive pneumococcal disease (IPD) before (2004–2005, n = 1154) and afte...

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Bibliographic Details
Published in:Vaccine 2012-12, Vol.30 (52), p.7644-7651
Main Authors: Elberse, Karin E.M, van der Heide, Han G.J, Witteveen, Sandra, van de Pol, Ingrid, Schot, Corrie S, van der Ende, Arie, Berbers, Guy A.M, Schouls, Leo M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Allergy and Immunology
Bacterial Capsules - genetics
Child
Child, Preschool
children
Female
Genes
genetic background
Heptavalent Pneumococcal Conjugate Vaccine
Herd immunity
herds
Humans
immunity
Immunization
Incidence
Infant
Infant, Newborn
IPD incidence
Laboratories
loci
Male
Meningitis
Meningitis, Pneumococcal - epidemiology
Meningitis, Pneumococcal - microbiology
Middle Aged
Minisatellite Repeats
MLVA
Molecular Epidemiology
Molecular typing
Multilocus Sequence Typing
Netherlands - epidemiology
patients
Pneumococcal conjugate vaccine
Pneumococcal population
Pneumococcal Vaccines - administration & dosage
Pneumococcal Vaccines - immunology
Pneumococcus
Pneumonia
serotypes
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - genetics
Streptococcus pneumoniae - isolation & purification
Temporal changes
vaccination
Vaccines
Young Adult
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Summary:Abstract The implementation of nationwide pneumococcal vaccination may lead to alterations in the pneumococcal population due to selective pressure induced by the vaccine. To monitor such changes, pneumococcal isolates causing invasive pneumococcal disease (IPD) before (2004–2005, n = 1154) and after (2008–2009, n = 1190) the implementation of the 7-valent pneumococcal vaccine (PCV7) in 2006 in the national immunization program (NIP) of The Netherlands were characterized by molecular typing using multiple-locus variable number tandem repeat analysis (MLVA) and capsular sequence typing (CST). The IPD incidence after the implementation of PCV7 in children
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.04.021