Low BDNF is associated with cognitive deficits in patients with type 2 diabetes

Objective Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the...

Full description

Saved in:
Bibliographic Details
Published in:Psychopharmacology 2013-05, Vol.227 (1), p.93-100
Main Authors: Zhen, Yan Feng, Zhang, Jia, Liu, Xing Yu, Fang, Hui, Tian, Luo Bing, Zhou, Dong Hao, Kosten, Thomas R, Zhang, Xiang Yang
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Cognition disorders
Cognition Disorders - blood
Cognition Disorders - epidemiology
Cognition Disorders - psychology
Cognitive ability
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - psychology
Female
Humans
Male
Memory
Middle Aged
Neuropsychological Tests
Neurosciences
Original Investigation
Pharmacology/Toxicology
Physiological aspects
Properties
Psychiatry
Psychological aspects
Psychomotor Performance - physiology
Psychopharmacology
Risk factors
Type 2 diabetes
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF with cognitive impairment in T2DM has not been investigated. Materials and methods We compared 208 patients with T2DM to 212 normal controls on serum BDNF and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results Serum BDNF levels were significantly decreased in T2DM patients compared to normal controls ( p  
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-012-2942-3