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Low BDNF is associated with cognitive deficits in patients with type 2 diabetes
Objective Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the...
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| Published in: | Psychopharmacology 2013-05, Vol.227 (1), p.93-100 |
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| Main Authors: | , , , , , , , |
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| container_start_page | 93 |
| container_title | Psychopharmacology |
| container_volume | 227 |
| creator | Zhen, Yan Feng Zhang, Jia Liu, Xing Yu Fang, Hui Tian, Luo Bing Zhou, Dong Hao Kosten, Thomas R Zhang, Xiang Yang |
| description | Objective
Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF with cognitive impairment in T2DM has not been investigated.
Materials and methods
We compared 208 patients with T2DM to 212 normal controls on serum BDNF and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).
Results
Serum BDNF levels were significantly decreased in T2DM patients compared to normal controls (
p
|
| doi_str_mv | 10.1007/s00213-012-2942-3 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1348488812</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A337619248</galeid><sourcerecordid>A337619248</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-f0bdcf4d66e8b141b96c66a8583f2c3f44e754973963d4929fbb4c177387df953</originalsourceid><addsrcrecordid>eNqNkU1vVCEUhonR2LH6A9wYEjdubgUOF7jLWq1tMrEbXRMuHEaamct4Ydr038s49TOaCAu-nveE97yEPOfshDOmXxfGBIeOcdGJQYoOHpAFl9BOTIuHZMEYQAe8N0fkSSnXrA1p5GNyJEAokIotyNUy39I3bz-c01SoKyX75CoGepvqZ-rzako13SANGJNPtdA00a2rCae2_8bUuy1SQUNyI1YsT8mj6NYFn92vx-TT-buPZxfd8ur95dnpsvNSi9pFNgYfZVAKzcglHwfllXKmNxCFhygl6l4OGgYFQQ5iiOMoPdcajA5x6OGYvDrU3c75yw5LtZtUPK7XbsK8K5ZDc2qM4eI_UKFa1xTwhr78A73Ou3lqRvZUz5USWv2kVm6NNk0x19n5fVF7CqAVH4Q0jTr5C9VmwE3yeWodbfe_CfhB4OdcyozRbue0cfOd5czu87aHvG3L2-7zttA0L-4_vBs3GH4ovgfcAHEASnuaVjj_4uifVb8CPNGwzw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1325166276</pqid></control><display><type>article</type><title>Low BDNF is associated with cognitive deficits in patients with type 2 diabetes</title><source>Springer Nature</source><source>SPORTDiscus</source><creator>Zhen, Yan Feng ; Zhang, Jia ; Liu, Xing Yu ; Fang, Hui ; Tian, Luo Bing ; Zhou, Dong Hao ; Kosten, Thomas R ; Zhang, Xiang Yang</creator><creatorcontrib>Zhen, Yan Feng ; Zhang, Jia ; Liu, Xing Yu ; Fang, Hui ; Tian, Luo Bing ; Zhou, Dong Hao ; Kosten, Thomas R ; Zhang, Xiang Yang</creatorcontrib><description>Objective
Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF with cognitive impairment in T2DM has not been investigated.
Materials and methods
We compared 208 patients with T2DM to 212 normal controls on serum BDNF and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).
Results
Serum BDNF levels were significantly decreased in T2DM patients compared to normal controls (
p
< 0.001). The total score and nearly all indexes (all
p
< 0.01) except for attention and visuospatial/constructional indexes (all
p
> 0.05) of RBANS were markedly lower in T2DM than controls. There was a positive relationship between serum BDNF and delayed memory in patients with T2DM.
Conclusion
Our results suggest that BDNF may play a role in the pathophysiology of cognitive deficits, especially delayed memory in T2DM.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-012-2942-3</identifier><identifier>PMID: 23263460</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - blood ; Cognition disorders ; Cognition Disorders - blood ; Cognition Disorders - epidemiology ; Cognition Disorders - psychology ; Cognitive ability ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - psychology ; Female ; Humans ; Male ; Memory ; Middle Aged ; Neuropsychological Tests ; Neurosciences ; Original Investigation ; Pharmacology/Toxicology ; Physiological aspects ; Properties ; Psychiatry ; Psychological aspects ; Psychomotor Performance - physiology ; Psychopharmacology ; Risk factors ; Type 2 diabetes ; Young Adult</subject><ispartof>Psychopharmacology, 2013-05, Vol.227 (1), p.93-100</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>COPYRIGHT 2013 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-f0bdcf4d66e8b141b96c66a8583f2c3f44e754973963d4929fbb4c177387df953</citedby><cites>FETCH-LOGICAL-c472t-f0bdcf4d66e8b141b96c66a8583f2c3f44e754973963d4929fbb4c177387df953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23263460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhen, Yan Feng</creatorcontrib><creatorcontrib>Zhang, Jia</creatorcontrib><creatorcontrib>Liu, Xing Yu</creatorcontrib><creatorcontrib>Fang, Hui</creatorcontrib><creatorcontrib>Tian, Luo Bing</creatorcontrib><creatorcontrib>Zhou, Dong Hao</creatorcontrib><creatorcontrib>Kosten, Thomas R</creatorcontrib><creatorcontrib>Zhang, Xiang Yang</creatorcontrib><title>Low BDNF is associated with cognitive deficits in patients with type 2 diabetes</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Objective
Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF with cognitive impairment in T2DM has not been investigated.
Materials and methods
We compared 208 patients with T2DM to 212 normal controls on serum BDNF and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).
Results
Serum BDNF levels were significantly decreased in T2DM patients compared to normal controls (
p
< 0.001). The total score and nearly all indexes (all
p
< 0.01) except for attention and visuospatial/constructional indexes (all
p
> 0.05) of RBANS were markedly lower in T2DM than controls. There was a positive relationship between serum BDNF and delayed memory in patients with T2DM.
Conclusion
Our results suggest that BDNF may play a role in the pathophysiology of cognitive deficits, especially delayed memory in T2DM.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Cognition disorders</subject><subject>Cognition Disorders - blood</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - psychology</subject><subject>Cognitive ability</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Neurosciences</subject><subject>Original Investigation</subject><subject>Pharmacology/Toxicology</subject><subject>Physiological aspects</subject><subject>Properties</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychopharmacology</subject><subject>Risk factors</subject><subject>Type 2 diabetes</subject><subject>Young Adult</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkU1vVCEUhonR2LH6A9wYEjdubgUOF7jLWq1tMrEbXRMuHEaamct4Ydr038s49TOaCAu-nveE97yEPOfshDOmXxfGBIeOcdGJQYoOHpAFl9BOTIuHZMEYQAe8N0fkSSnXrA1p5GNyJEAokIotyNUy39I3bz-c01SoKyX75CoGepvqZ-rzako13SANGJNPtdA00a2rCae2_8bUuy1SQUNyI1YsT8mj6NYFn92vx-TT-buPZxfd8ur95dnpsvNSi9pFNgYfZVAKzcglHwfllXKmNxCFhygl6l4OGgYFQQ5iiOMoPdcajA5x6OGYvDrU3c75yw5LtZtUPK7XbsK8K5ZDc2qM4eI_UKFa1xTwhr78A73Ou3lqRvZUz5USWv2kVm6NNk0x19n5fVF7CqAVH4Q0jTr5C9VmwE3yeWodbfe_CfhB4OdcyozRbue0cfOd5czu87aHvG3L2-7zttA0L-4_vBs3GH4ovgfcAHEASnuaVjj_4uifVb8CPNGwzw</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Zhen, Yan Feng</creator><creator>Zhang, Jia</creator><creator>Liu, Xing Yu</creator><creator>Fang, Hui</creator><creator>Tian, Luo Bing</creator><creator>Zhou, Dong Hao</creator><creator>Kosten, Thomas R</creator><creator>Zhang, Xiang Yang</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Low BDNF is associated with cognitive deficits in patients with type 2 diabetes</title><author>Zhen, Yan Feng ; Zhang, Jia ; Liu, Xing Yu ; Fang, Hui ; Tian, Luo Bing ; Zhou, Dong Hao ; Kosten, Thomas R ; Zhang, Xiang Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-f0bdcf4d66e8b141b96c66a8583f2c3f44e754973963d4929fbb4c177387df953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Cognition disorders</topic><topic>Cognition Disorders - blood</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - psychology</topic><topic>Cognitive ability</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Neurosciences</topic><topic>Original Investigation</topic><topic>Pharmacology/Toxicology</topic><topic>Physiological aspects</topic><topic>Properties</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Psychomotor Performance - physiology</topic><topic>Psychopharmacology</topic><topic>Risk factors</topic><topic>Type 2 diabetes</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhen, Yan Feng</creatorcontrib><creatorcontrib>Zhang, Jia</creatorcontrib><creatorcontrib>Liu, Xing Yu</creatorcontrib><creatorcontrib>Fang, Hui</creatorcontrib><creatorcontrib>Tian, Luo Bing</creatorcontrib><creatorcontrib>Zhou, Dong Hao</creatorcontrib><creatorcontrib>Kosten, Thomas R</creatorcontrib><creatorcontrib>Zhang, Xiang Yang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhen, Yan Feng</au><au>Zhang, Jia</au><au>Liu, Xing Yu</au><au>Fang, Hui</au><au>Tian, Luo Bing</au><au>Zhou, Dong Hao</au><au>Kosten, Thomas R</au><au>Zhang, Xiang Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low BDNF is associated with cognitive deficits in patients with type 2 diabetes</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>227</volume><issue>1</issue><spage>93</spage><epage>100</epage><pages>93-100</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Objective
Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF with cognitive impairment in T2DM has not been investigated.
Materials and methods
We compared 208 patients with T2DM to 212 normal controls on serum BDNF and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).
Results
Serum BDNF levels were significantly decreased in T2DM patients compared to normal controls (
p
< 0.001). The total score and nearly all indexes (all
p
< 0.01) except for attention and visuospatial/constructional indexes (all
p
> 0.05) of RBANS were markedly lower in T2DM than controls. There was a positive relationship between serum BDNF and delayed memory in patients with T2DM.
Conclusion
Our results suggest that BDNF may play a role in the pathophysiology of cognitive deficits, especially delayed memory in T2DM.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23263460</pmid><doi>10.1007/s00213-012-2942-3</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacology, 2013-05, Vol.227 (1), p.93-100 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1348488812 |
| source | Springer Nature; SPORTDiscus |
| subjects | Adult Aged Biomarkers - blood Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Cognition disorders Cognition Disorders - blood Cognition Disorders - epidemiology Cognition Disorders - psychology Cognitive ability Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - psychology Female Humans Male Memory Middle Aged Neuropsychological Tests Neurosciences Original Investigation Pharmacology/Toxicology Physiological aspects Properties Psychiatry Psychological aspects Psychomotor Performance - physiology Psychopharmacology Risk factors Type 2 diabetes Young Adult |
| title | Low BDNF is associated with cognitive deficits in patients with type 2 diabetes |
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