Cell apoptosis and proliferation in salivary glands of Sjögren's syndrome

J Oral Pathol Med (2011) 40: 721–725 Background:  Sjögren’s syndrome (SS) occurs associated with parotid neoplasm, non‐Hodgkin’s B‐cell lymphoma, which could impair the condition or be life‐threatening for patients. The aim of this work was to analyze cell proliferation and apoptosis modifications i...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2011-10, Vol.40 (9), p.721-725
Main Authors: Busamia, B., Gonzalez-Moles, M. A., Ruiz-Avila, I., Brunotto, M., Gil-Montoya, J. A., Bravo, M., Gobbi, C., Finkelberg, A.
Format: Article
Language:English
Subjects:
apoptosis
Apoptosis - physiology
Biological and medical sciences
Caspase 3 - analysis
caspase-3
Cell Proliferation
Cell Transformation, Neoplastic - pathology
Dentistry
Humans
Keratoconjunctivitis - pathology
Ki-67
Ki-67 Antigen - analysis
Lip - pathology
Lymphocytes - pathology
Medical sciences
Otorhinolaryngology. Stomatology
proliferation
Risk Factors
Salivary Ducts - pathology
Salivary Glands - pathology
Salivary Glands, Minor - pathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sialadenitis - pathology
Sjogren's Syndrome - pathology
Sjögren's syndrome
Xerostomia - pathology
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Summary:J Oral Pathol Med (2011) 40: 721–725 Background:  Sjögren’s syndrome (SS) occurs associated with parotid neoplasm, non‐Hodgkin’s B‐cell lymphoma, which could impair the condition or be life‐threatening for patients. The aim of this work was to analyze cell proliferation and apoptosis modifications in acinar, ductal and inflammatory infiltrate in salivary glands (SG) in patients with Sjögren Syndrome, keratoconjunctivitis, or stomatitis sicca or in healthy subjects, to establish parameters that indicate the likelihood of malignancy of the disease in populations at risk. Methods:  A study was performed with n = 58 histological samples of lower lip SG from patients diagnosed with SS, keratoconjunctivitis, or stomatitis sicca (SICCA) and from healthy subjects (C). Ki67 and caspase‐3 immunolabeling were performed. Results:  The most important result was significant differences between the three study groups in Ki67 and caspase‐3 markers (P 
ISSN:0904-2512
1600-0714
DOI:10.1111/j.1600-0714.2011.01042.x