Altered MARCH1 ubiquination-regulated dendritic cell immune functions during the early stage of zymosan-induced multiple organ dysfunction syndrome (MODS) in mice

Highlights ► IL-12 and TNF-α expressions in spleen CD11c+ DCs were increased in MODS 1 d mice. ► MODS 1 d DCs reduced MARCH1 mRNA expression that regulates MHC-II expression. ► Silencing DCs MARCH1 expression resulted in enhancing induction of T cell function. ► MARCH1 may regulate function of DC ce...

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Bibliographic Details
Published in:Immunology letters 2013-02, Vol.150 (1), p.105-115
Main Authors: Li, Fei, Lu, Jiang-yang, Liu, Qian, Wang, Hong-wei, Guo, Huiqin
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
CD11c Antigen - metabolism
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Disease Models, Animal
Disease Progression
Gene Expression
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Lymphocyte Activation - immunology
Male
MARCH1
Mice
MODS
Multiple Organ Failure - chemically induced
Multiple Organ Failure - immunology
Multiple Organ Failure - metabolism
Proteasome Endopeptidase Complex - metabolism
Proteolysis
RNA Interference
Spleen - cytology
Spleen - immunology
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Ubiquinated-proteins
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
Ubiquitination
Zymosan - adverse effects
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Description
Summary:Highlights ► IL-12 and TNF-α expressions in spleen CD11c+ DCs were increased in MODS 1 d mice. ► MODS 1 d DCs reduced MARCH1 mRNA expression that regulates MHC-II expression. ► Silencing DCs MARCH1 expression resulted in enhancing induction of T cell function. ► MARCH1 may regulate function of DC cells through ubiquitination of surface MHC-II.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2012.12.012