Coffee consumption and risk of colorectal cancer: a dose–response analysis of observational studies

Coffee consumption has been linked to risk of colorectal cancer theoretically, but the findings were conflicting from observational studies. Results from the recent meta-analysis suggested a moderate favorable effect of coffee consumption on colorectal cancer risk, especially for colon cancer. Howev...

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Bibliographic Details
Published in:Cancer causes & control 2013-06, Vol.24 (6), p.1265-1268
Main Authors: Tian, Changwei, Wang, Wenming, Hong, Zhiqiang, Zhang, Xingliang
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer Research
Case control studies
Coffee
Cohort studies
Colorectal cancer
Colorectal Neoplasms - epidemiology
Confidence interval
Dose response relationship
Dose-Response Relationship, Drug
Epidemiology
Female
Hematology
Humans
LETTER TO THE EDITOR
Male
Maximum likelihood estimation
Men
Meta analysis
Meta-Analysis as Topic
Observational studies
Observational Studies as Topic
Oncology
Public Health
Risk Factors
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Summary:Coffee consumption has been linked to risk of colorectal cancer theoretically, but the findings were conflicting from observational studies. Results from the recent meta-analysis suggested a moderate favorable effect of coffee consumption on colorectal cancer risk, especially for colon cancer. However, the relationship, if exists, between coffee consumption and colorectal cancer risk is unclear. Thus, the dose–response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression. The results suggested that a significant association was found between coffee consumption and decreased risk of colorectal and colon cancer among subjects consuming ≥4 cups of coffee per day. A potential nonlinear relationship should be assessed before assuming a linear relationship.
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-013-0200-6