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Vitamin D3 levels and insulin resistance in papillary thyroid cancer patients
Both insulin resistance (IR) and vitamin D deficiency (VDD) are found to be associated with many cancer types. In this study, we evaluated the presence of IR and VDD in thyroid cancer patients based on controls. Total 344 papillary thyroid cancer and 116 controls were part of the study. Glucose, ins...
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| Published in: | Medical oncology (Northwood, London, England) London, England), 2013-06, Vol.30 (2), p.589-589, Article 589 |
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| container_end_page | 589 |
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| container_title | Medical oncology (Northwood, London, England) |
| container_volume | 30 |
| creator | Şahin, Mustafa Uçan, Bekir Giniş, Zeynep Topaloğlu, Oya Güngüneş, Aşkın Bozkurt, Nujen Çolak Arslan, Müyesser Sayki Ünsal, İlknur Öztürk Akkaymak, Esra Tutal Demirci, Taner Karaköse, Melia Çalışkan, Mustafa Çakal, Erman Özbek, Mustafa Delibaşı, Tuncay |
| description | Both insulin resistance (IR) and vitamin D deficiency (VDD) are found to be associated with many cancer types. In this study, we evaluated the presence of IR and VDD in thyroid cancer patients based on controls. Total 344 papillary thyroid cancer and 116 controls were part of the study. Glucose, insulin, homeostasis model analysis-insulin resistance (HOMA-IR) (control group 2.12 ± 0.9 and patient group 3.6 ± 1.1;
p
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| doi_str_mv | 10.1007/s12032-013-0589-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1349095498</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2983077221</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-e62db457598ac89f0c853c73884fc80b3203342244caccbc1d85ddc665095a873</originalsourceid><addsrcrecordid>eNp1kEtLxDAUhYMozjj6A9xIwY2bap5tspTxCSNuVNyFNE01Q5vWpBXm35vSUURwlXDPd8-99wBwjOA5gjC_CAhDglOISAoZFynbAXPEmEgRQa-78U9YHpUMzsBBCGsIMWJY7IMZJhlljGZz8PBie9VYl1yRpDafpg6JcmViXRjqWPUm2NArp00sJZ3qbF0rv0n6941vbZnoUfJR6K1xfTgEe5WqgznavgvwfHP9tLxLV4-398vLVapJjvvUZLgsKMuZ4EpzUUHNGdE54ZxWmsOCxLMIxZhSrbQuNCo5K0udZQwKpnhOFuBs8u18-zGY0MvGBm3ibs60Q5CIUBFRKnhET_-g63bwLm4XKZZRSmg-UmiitG9D8KaSnbdNvFQiKMes5ZS1jFnLMWvJYs_J1nkoGlP-dHyHGwE8ASFK7s34X6P_df0CmaOIWw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1356443478</pqid></control><display><type>article</type><title>Vitamin D3 levels and insulin resistance in papillary thyroid cancer patients</title><source>Springer Link</source><creator>Şahin, Mustafa ; Uçan, Bekir ; Giniş, Zeynep ; Topaloğlu, Oya ; Güngüneş, Aşkın ; Bozkurt, Nujen Çolak ; Arslan, Müyesser Sayki ; Ünsal, İlknur Öztürk ; Akkaymak, Esra Tutal ; Demirci, Taner ; Karaköse, Melia ; Çalışkan, Mustafa ; Çakal, Erman ; Özbek, Mustafa ; Delibaşı, Tuncay</creator><creatorcontrib>Şahin, Mustafa ; Uçan, Bekir ; Giniş, Zeynep ; Topaloğlu, Oya ; Güngüneş, Aşkın ; Bozkurt, Nujen Çolak ; Arslan, Müyesser Sayki ; Ünsal, İlknur Öztürk ; Akkaymak, Esra Tutal ; Demirci, Taner ; Karaköse, Melia ; Çalışkan, Mustafa ; Çakal, Erman ; Özbek, Mustafa ; Delibaşı, Tuncay</creatorcontrib><description>Both insulin resistance (IR) and vitamin D deficiency (VDD) are found to be associated with many cancer types. In this study, we evaluated the presence of IR and VDD in thyroid cancer patients based on controls. Total 344 papillary thyroid cancer and 116 controls were part of the study. Glucose, insulin, homeostasis model analysis-insulin resistance (HOMA-IR) (control group 2.12 ± 0.9 and patient group 3.6 ± 1.1;
p
< 0.0001), LDL were significantly high; HOMA-S and vitamin D3 levels (control group 19.11 ± 8 and patient group 17 ± 16;
p
= 0.004) were significantly low in the patient group. Vitamin D deficiency (64/108 in controls vs 166/235;
p
= 0.026) and insulin resistance (24/108; 115/235;
p
< 0.0001) were more frequent in papillary thyroid cancer patients. After regression analysis, tumor diameter showed significant association with log-HOMA-IR (
B
= 0.315;
p
= 0.017) and log-vitamin D3 (
B
= 0.207;
p
= 0.04). Vitamin D deficiency and insulin resistance frequencies show no difference between micro- and macropapillary thyroid cancers. Receiver operating characteristic curve shows the best cutoff point for tumor diameter showing that the presence of lymph node metastasis was 0.65 cm with 81.2 % sensitivity and 52 % specificity. Best cutoff point for the capsular invasion tumor diameter was 0.75 cm with 83.3 % sensitivity and 60.4 % specificity. No difference between follicular and classical type papillary thyroid carcinomas has been yet discovered. As a result, thyroid cancer patients are more insulin resistant and vitamin D3 deficient. Vitamin D3 levels and HOMA-IR index may affect tumor diameter. Tumor size that is lower than 1 cm (0.65–0.75 cm) may be related with capsular invasion and lymph node involvement.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-013-0589-5</identifier><identifier>PMID: 23645546</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Carcinoma - blood ; Carcinoma, Papillary ; Case-Control Studies ; Cholecalciferol - blood ; Cholecalciferol - deficiency ; Female ; Folic Acid - blood ; Hematology ; Homeostasis ; Humans ; Insulin Resistance ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Paper ; Pathology ; ROC Curve ; Thyroglobulin - blood ; Thyroid Cancer, Papillary ; Thyroid Neoplasms - blood ; Vitamin B 12 - blood</subject><ispartof>Medical oncology (Northwood, London, England), 2013-06, Vol.30 (2), p.589-589, Article 589</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-e62db457598ac89f0c853c73884fc80b3203342244caccbc1d85ddc665095a873</citedby><cites>FETCH-LOGICAL-c372t-e62db457598ac89f0c853c73884fc80b3203342244caccbc1d85ddc665095a873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23645546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Şahin, Mustafa</creatorcontrib><creatorcontrib>Uçan, Bekir</creatorcontrib><creatorcontrib>Giniş, Zeynep</creatorcontrib><creatorcontrib>Topaloğlu, Oya</creatorcontrib><creatorcontrib>Güngüneş, Aşkın</creatorcontrib><creatorcontrib>Bozkurt, Nujen Çolak</creatorcontrib><creatorcontrib>Arslan, Müyesser Sayki</creatorcontrib><creatorcontrib>Ünsal, İlknur Öztürk</creatorcontrib><creatorcontrib>Akkaymak, Esra Tutal</creatorcontrib><creatorcontrib>Demirci, Taner</creatorcontrib><creatorcontrib>Karaköse, Melia</creatorcontrib><creatorcontrib>Çalışkan, Mustafa</creatorcontrib><creatorcontrib>Çakal, Erman</creatorcontrib><creatorcontrib>Özbek, Mustafa</creatorcontrib><creatorcontrib>Delibaşı, Tuncay</creatorcontrib><title>Vitamin D3 levels and insulin resistance in papillary thyroid cancer patients</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>Both insulin resistance (IR) and vitamin D deficiency (VDD) are found to be associated with many cancer types. In this study, we evaluated the presence of IR and VDD in thyroid cancer patients based on controls. Total 344 papillary thyroid cancer and 116 controls were part of the study. Glucose, insulin, homeostasis model analysis-insulin resistance (HOMA-IR) (control group 2.12 ± 0.9 and patient group 3.6 ± 1.1;
p
< 0.0001), LDL were significantly high; HOMA-S and vitamin D3 levels (control group 19.11 ± 8 and patient group 17 ± 16;
p
= 0.004) were significantly low in the patient group. Vitamin D deficiency (64/108 in controls vs 166/235;
p
= 0.026) and insulin resistance (24/108; 115/235;
p
< 0.0001) were more frequent in papillary thyroid cancer patients. After regression analysis, tumor diameter showed significant association with log-HOMA-IR (
B
= 0.315;
p
= 0.017) and log-vitamin D3 (
B
= 0.207;
p
= 0.04). Vitamin D deficiency and insulin resistance frequencies show no difference between micro- and macropapillary thyroid cancers. Receiver operating characteristic curve shows the best cutoff point for tumor diameter showing that the presence of lymph node metastasis was 0.65 cm with 81.2 % sensitivity and 52 % specificity. Best cutoff point for the capsular invasion tumor diameter was 0.75 cm with 83.3 % sensitivity and 60.4 % specificity. No difference between follicular and classical type papillary thyroid carcinomas has been yet discovered. As a result, thyroid cancer patients are more insulin resistant and vitamin D3 deficient. Vitamin D3 levels and HOMA-IR index may affect tumor diameter. Tumor size that is lower than 1 cm (0.65–0.75 cm) may be related with capsular invasion and lymph node involvement.</description><subject>Adult</subject><subject>Carcinoma - blood</subject><subject>Carcinoma, Papillary</subject><subject>Case-Control Studies</subject><subject>Cholecalciferol - blood</subject><subject>Cholecalciferol - deficiency</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Hematology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>ROC Curve</subject><subject>Thyroglobulin - blood</subject><subject>Thyroid Cancer, Papillary</subject><subject>Thyroid Neoplasms - blood</subject><subject>Vitamin B 12 - blood</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLxDAUhYMozjj6A9xIwY2bap5tspTxCSNuVNyFNE01Q5vWpBXm35vSUURwlXDPd8-99wBwjOA5gjC_CAhDglOISAoZFynbAXPEmEgRQa-78U9YHpUMzsBBCGsIMWJY7IMZJhlljGZz8PBie9VYl1yRpDafpg6JcmViXRjqWPUm2NArp00sJZ3qbF0rv0n6941vbZnoUfJR6K1xfTgEe5WqgznavgvwfHP9tLxLV4-398vLVapJjvvUZLgsKMuZ4EpzUUHNGdE54ZxWmsOCxLMIxZhSrbQuNCo5K0udZQwKpnhOFuBs8u18-zGY0MvGBm3ibs60Q5CIUBFRKnhET_-g63bwLm4XKZZRSmg-UmiitG9D8KaSnbdNvFQiKMes5ZS1jFnLMWvJYs_J1nkoGlP-dHyHGwE8ASFK7s34X6P_df0CmaOIWw</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Şahin, Mustafa</creator><creator>Uçan, Bekir</creator><creator>Giniş, Zeynep</creator><creator>Topaloğlu, Oya</creator><creator>Güngüneş, Aşkın</creator><creator>Bozkurt, Nujen Çolak</creator><creator>Arslan, Müyesser Sayki</creator><creator>Ünsal, İlknur Öztürk</creator><creator>Akkaymak, Esra Tutal</creator><creator>Demirci, Taner</creator><creator>Karaköse, Melia</creator><creator>Çalışkan, Mustafa</creator><creator>Çakal, Erman</creator><creator>Özbek, Mustafa</creator><creator>Delibaşı, Tuncay</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Vitamin D3 levels and insulin resistance in papillary thyroid cancer patients</title><author>Şahin, Mustafa ; Uçan, Bekir ; Giniş, Zeynep ; Topaloğlu, Oya ; Güngüneş, Aşkın ; Bozkurt, Nujen Çolak ; Arslan, Müyesser Sayki ; Ünsal, İlknur Öztürk ; Akkaymak, Esra Tutal ; Demirci, Taner ; Karaköse, Melia ; Çalışkan, Mustafa ; Çakal, Erman ; Özbek, Mustafa ; Delibaşı, Tuncay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-e62db457598ac89f0c853c73884fc80b3203342244caccbc1d85ddc665095a873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Carcinoma - blood</topic><topic>Carcinoma, Papillary</topic><topic>Case-Control Studies</topic><topic>Cholecalciferol - blood</topic><topic>Cholecalciferol - deficiency</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>Hematology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>ROC Curve</topic><topic>Thyroglobulin - blood</topic><topic>Thyroid Cancer, Papillary</topic><topic>Thyroid Neoplasms - blood</topic><topic>Vitamin B 12 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Şahin, Mustafa</creatorcontrib><creatorcontrib>Uçan, Bekir</creatorcontrib><creatorcontrib>Giniş, Zeynep</creatorcontrib><creatorcontrib>Topaloğlu, Oya</creatorcontrib><creatorcontrib>Güngüneş, Aşkın</creatorcontrib><creatorcontrib>Bozkurt, Nujen Çolak</creatorcontrib><creatorcontrib>Arslan, Müyesser Sayki</creatorcontrib><creatorcontrib>Ünsal, İlknur Öztürk</creatorcontrib><creatorcontrib>Akkaymak, Esra Tutal</creatorcontrib><creatorcontrib>Demirci, Taner</creatorcontrib><creatorcontrib>Karaköse, Melia</creatorcontrib><creatorcontrib>Çalışkan, Mustafa</creatorcontrib><creatorcontrib>Çakal, Erman</creatorcontrib><creatorcontrib>Özbek, Mustafa</creatorcontrib><creatorcontrib>Delibaşı, Tuncay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Şahin, Mustafa</au><au>Uçan, Bekir</au><au>Giniş, Zeynep</au><au>Topaloğlu, Oya</au><au>Güngüneş, Aşkın</au><au>Bozkurt, Nujen Çolak</au><au>Arslan, Müyesser Sayki</au><au>Ünsal, İlknur Öztürk</au><au>Akkaymak, Esra Tutal</au><au>Demirci, Taner</au><au>Karaköse, Melia</au><au>Çalışkan, Mustafa</au><au>Çakal, Erman</au><au>Özbek, Mustafa</au><au>Delibaşı, Tuncay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D3 levels and insulin resistance in papillary thyroid cancer patients</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>30</volume><issue>2</issue><spage>589</spage><epage>589</epage><pages>589-589</pages><artnum>589</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>Both insulin resistance (IR) and vitamin D deficiency (VDD) are found to be associated with many cancer types. In this study, we evaluated the presence of IR and VDD in thyroid cancer patients based on controls. Total 344 papillary thyroid cancer and 116 controls were part of the study. Glucose, insulin, homeostasis model analysis-insulin resistance (HOMA-IR) (control group 2.12 ± 0.9 and patient group 3.6 ± 1.1;
p
< 0.0001), LDL were significantly high; HOMA-S and vitamin D3 levels (control group 19.11 ± 8 and patient group 17 ± 16;
p
= 0.004) were significantly low in the patient group. Vitamin D deficiency (64/108 in controls vs 166/235;
p
= 0.026) and insulin resistance (24/108; 115/235;
p
< 0.0001) were more frequent in papillary thyroid cancer patients. After regression analysis, tumor diameter showed significant association with log-HOMA-IR (
B
= 0.315;
p
= 0.017) and log-vitamin D3 (
B
= 0.207;
p
= 0.04). Vitamin D deficiency and insulin resistance frequencies show no difference between micro- and macropapillary thyroid cancers. Receiver operating characteristic curve shows the best cutoff point for tumor diameter showing that the presence of lymph node metastasis was 0.65 cm with 81.2 % sensitivity and 52 % specificity. Best cutoff point for the capsular invasion tumor diameter was 0.75 cm with 83.3 % sensitivity and 60.4 % specificity. No difference between follicular and classical type papillary thyroid carcinomas has been yet discovered. As a result, thyroid cancer patients are more insulin resistant and vitamin D3 deficient. Vitamin D3 levels and HOMA-IR index may affect tumor diameter. Tumor size that is lower than 1 cm (0.65–0.75 cm) may be related with capsular invasion and lymph node involvement.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23645546</pmid><doi>10.1007/s12032-013-0589-5</doi><tpages>1</tpages></addata></record> |
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| ispartof | Medical oncology (Northwood, London, England), 2013-06, Vol.30 (2), p.589-589, Article 589 |
| issn | 1357-0560 1559-131X |
| language | eng |
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| subjects | Adult Carcinoma - blood Carcinoma, Papillary Case-Control Studies Cholecalciferol - blood Cholecalciferol - deficiency Female Folic Acid - blood Hematology Homeostasis Humans Insulin Resistance Internal Medicine Male Medicine Medicine & Public Health Middle Aged Oncology Original Paper Pathology ROC Curve Thyroglobulin - blood Thyroid Cancer, Papillary Thyroid Neoplasms - blood Vitamin B 12 - blood |
| title | Vitamin D3 levels and insulin resistance in papillary thyroid cancer patients |
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