High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade

The objectives of this work are to study angiogenesis in pancreatic ductal adenocarcinoma using computerized morphometric and image analysis and to compare the microvascular density in intratumoral and peritumoral areas and normal pancreatic tissue. Microvascular density was analyzed in 60 cases of...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2013-05, Vol.462 (5), p.541-546
Main Authors: Barău, Anca, Ruiz-Sauri, Amparo, Valencia, Gerardo, Gómez-Mateo, Maria del Carmen, Sabater, Luis, Ferrandez, Antonio, Llombart-Bosch, Antonio
Format: Article
Language:English
Subjects:
Aged
Biotin
Carcinoma, Pancreatic Ductal - blood supply
Carcinoma, Pancreatic Ductal - pathology
Female
Humans
Image Interpretation, Computer-Assisted
Male
Medicine
Medicine & Public Health
Microvessels - pathology
Middle Aged
Neoplasm Grading
Neovascularization, Pathologic - pathology
Original Article
Pancreatic Neoplasms - blood supply
Pancreatic Neoplasms - pathology
Pathology
Tissues
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Summary:The objectives of this work are to study angiogenesis in pancreatic ductal adenocarcinoma using computerized morphometric and image analysis and to compare the microvascular density in intratumoral and peritumoral areas and normal pancreatic tissue. Microvascular density was analyzed in 60 cases of pancreatic ductal adenocarcinoma and 30 samples of normal pancreatic tissue using an avidin–biotin immunoperoxidase technique with an anti-CD31 antibody. Microvascular density (MVD) was analyzed through digital microimaging and computerized analysis. The blood vessel density in the tumor was significantly higher than in peritumoral areas and in normal pancreatic tissue. Well differentiated pancreatic ductal adenocarcinomas contained higher MVD than poorly differentiated carcinomas. In pancreatic adenocarcinoma, MVD is higher than in peritumoral tissue or normal pancreatic tissue.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-013-1409-1