The Protective Effects of Piceatannol from Passion Fruit (Passiflora edulis) Seeds in UVB-Irradiated Keratinocytes

The use of naturally occurring botanicals with substantial antioxidant activity to prevent photoageing is receiving increasing attention. We have previously identified piceatannol and scirpusin B, which is a dimer of piceatannol, as strong antioxidants that are present in passion fruit (Passiflora e...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2013/05/01, Vol.36(5), pp.845-849
Main Authors: Maruki-Uchida, Hiroko, Kurita, Ikuko, Sugiyama, Kenkichi, Sai, Masahiko, Maeda, Kazuhisa, Ito, Tatsuhiko
Format: Article
Language:English
Subjects:
Benzofurans - pharmacology
Cell Line
Cells
Glutathione - metabolism
Humans
keratinocyte
Keratinocytes - drug effects
Keratinocytes - metabolism
Keratinocytes - radiation effects
Matrix Metalloproteinase 1 - metabolism
matrix-metalloproteinase
Passiflora
passion fruit seed
piceatannol
Plant Extracts - pharmacology
Radiation-Protective Agents - pharmacology
reactive oxygen species
Reactive Oxygen Species - metabolism
Seeds
Skin Aging
Stilbenes - pharmacology
ultraviolet
Ultraviolet Rays - adverse effects
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Summary:The use of naturally occurring botanicals with substantial antioxidant activity to prevent photoageing is receiving increasing attention. We have previously identified piceatannol and scirpusin B, which is a dimer of piceatannol, as strong antioxidants that are present in passion fruit (Passiflora edulis) seeds. In the present study, the effects of passion fruit seed extract, piceatannol, and scirpusin B on human keratinocytes were investigated. The passion fruit seed extract and piceatannol upregulated the glutathione (GSH) levels in keratinocytes in a dose-dependent manner, indicating that piceatannol is an active component of the passion fruit seed extract in keratinocytes. The pretreatment with piceatannol also supressed the UVB-induced generation of reactive oxygen species (ROS) in the keratinocytes. In addition, the transfer of the medium from the UVB-irradiated keratinocytes to non-irradiated fibroblasts enhanced matrix-metalloproteinase (MMP)-1 activity, and this MMP-1 induction was reduced when the keratinocytes were pretreated with piceatannol. These results suggest that piceatannol attenuates the UVB-induced activity of MMP-1 along with a reduction of ROS generation in keratinocytes. Thus, piceatannol and passion fruit seed extract containing high amounts of piceatannol are potential anti-photoageing cosmetic ingredients.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b12-00708