Date (Phoenix dactylifera L.) Fruit Soluble Phenolics Composition and Anti-atherogenic Properties in Nine Israeli Varieties

Date (Phoenix dactylifera L.) fruit soluble phenolics composition and anti-atherogenic properties were examined in nine diverse Israeli grown varieties. Ethanol and acetone extracts of ‘Amari’, ‘Barhi’, ‘Deglet Noor’, ‘Deri’, ‘Hadrawi’, ‘Hallawi’, ‘Hayani’, ‘Medjool’, and ‘Zahidi’ fruit were analyze...

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Published in:Journal of agricultural and food chemistry 2013-05, Vol.61 (18), p.4278-4286
Main Authors: Borochov-Neori, Hamutal, Judeinstein, Sylvie, Greenberg, Amnon, Volkova, Nina, Rosenblat, Mira, Aviram, Michael
Format: Article
Language:English
Subjects:
Acetone
Animals
Antioxidants - chemistry
Arecaceae - chemistry
Arecaceae - classification
bioactive properties
Biological and medical sciences
Cell Line, Tumor
cholesterol
Chromatography, High Pressure Liquid
Copper - metabolism
Ethanol
flavonols
Food industries
Fruit - chemistry
Fruit and vegetable industries
Fundamental and applied biological sciences. Psychology
Humans
ingredients
Israel
Lipid Metabolism - drug effects
Lipoproteins, LDL - blood
low density lipoprotein
macrophages
Macrophages - chemistry
Macrophages - drug effects
Mice
oxidation
phenolic compounds
Phenols - chemistry
Phoenix dactylifera
reversed-phase high performance liquid chromatography
solvents
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:Date (Phoenix dactylifera L.) fruit soluble phenolics composition and anti-atherogenic properties were examined in nine diverse Israeli grown varieties. Ethanol and acetone extracts of ‘Amari’, ‘Barhi’, ‘Deglet Noor’, ‘Deri’, ‘Hadrawi’, ‘Hallawi’, ‘Hayani’, ‘Medjool’, and ‘Zahidi’ fruit were analyzed for phenolics composition by RP-HPLC and tested for anti-atherogenicity by measuring their effects on LDL susceptibility to copper ion- and free radical-induced oxidation, and on serum-mediated cholesterol efflux from macrophages. The most frequently detected phenolics were hydroxybenzoates, hydroxycinnamates, and flavonols. Significant differences in phenolics composition were established between varieties as well as extraction solvents. All extracts inhibited LDL oxidation, and most extracts also stimulated cholesterol removal from macrophages. Considerable varietal differences were measured in the levels of the bioactivities. Also, acetone extracts exhibited a significantly higher anti-atherogenic potency for most varieties. The presence of soluble ingredients with anti-atherogenic capacities in dates and the possible involvement of phenolics are discussed.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf400782v