Effect of Antioxidants and Nitric Oxide on Activity of Peritoneal Macrophages in Albino Rats during Normal Pregnancy

We compared activity of peritoneal macrophages in rats during normal pregnancy and under the action of NO-synthase inhibitor L-NAME, of E. coli LPS , SOD, and α-tocopherol analogue trolox. In non-pregnant rats, E. coli LPS stimulated peritoneal macrophages, while L-NAME produced a dose-dependent eff...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-03, Vol.154 (5), p.581-583
Main Authors: Ivanova, A. S., Popova, I. G., Nazarov, S. B.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chromans - pharmacology
Escherichia coli
Female
Internal Medicine
Laboratory Medicine
Lipopolysaccharides - pharmacology
Macrophage Activation - drug effects
Macrophages
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - immunology
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide
Nitric Oxide - pharmacology
Nitric Oxide Synthase - antagonists & inhibitors
Pathology
Phagocytosis - drug effects
Physiology
Pregnancy
Rats
Superoxide Dismutase - pharmacology
Tocopherols
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Summary:We compared activity of peritoneal macrophages in rats during normal pregnancy and under the action of NO-synthase inhibitor L-NAME, of E. coli LPS , SOD, and α-tocopherol analogue trolox. In non-pregnant rats, E. coli LPS stimulated peritoneal macrophages, while L-NAME produced a dose-dependent effect. During pregnancy, E. coli LPS activated phagocytosis, while antioxidants trolox, SOD, and L-NAME produced an inhibitory effect.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2003-x