Evaluation of Hepatoprotective Activity of Water-Soluble Polysaccharide Fraction of Stellaria Media L

Therapy of rats with CCl 4 hepatitis with Stellaria media L. water-soluble polysaccharide fraction in a dose of 100 mg/kg reduces serum activities of transaminases (ALT and AST), alkaline phosphatase, bilirubin, and the thymol test values. In the liver, the density of inflammatory infiltration of th...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-03, Vol.154 (5), p.645-648
Main Authors: Gorina, Ya. V., Saprykina, E. V., Gereng, E. A., Perevozchikova, T. V., Krasnov, E. A., Ivanova, E. V., Fait, E. A., Baranova, O. V.
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Alanine Transaminase - metabolism
Alkaline Phosphatase - blood
Alkaline Phosphatase - metabolism
Animals
Aspartate Aminotransferases - blood
Aspartate Aminotransferases - metabolism
Bilirubin
Bilirubin - blood
Bilirubin - metabolism
Biomedical and Life Sciences
Biomedicine
Carbon Tetrachloride
Cell Biology
Hepatitis
Hepatitis - drug therapy
Hepatocytes - drug effects
Internal Medicine
Laboratory Medicine
Liver - drug effects
Liver - pathology
Liver Function Tests
Male
Pathology
Phytotherapy
Plant Preparations - therapeutic use
Polysaccharides
Polysaccharides - therapeutic use
Rats
Solubility
Stellaria - chemistry
Thymolphthalein - analogs & derivatives
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Summary:Therapy of rats with CCl 4 hepatitis with Stellaria media L. water-soluble polysaccharide fraction in a dose of 100 mg/kg reduces serum activities of transaminases (ALT and AST), alkaline phosphatase, bilirubin, and the thymol test values. In the liver, the density of inflammatory infiltration of the organ parenchyma, total count of necrotic hepatocytes, fatty and protein degeneration are reducing. Hence, water-soluble polysaccharide fraction, isolated from the terrestrial part of Stellaria media L. , is characterized by hepatoprotective activity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2021-8