Transcriptional Regulation of Endothelial Cell and Vascular Development

The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the pathogenesis of vascular diseases. Here, we review the und...

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Bibliographic Details
Published in:Circulation research 2013-05, Vol.112 (10), p.1380-1400
Main Authors: Park, Changwon, Kim, Tae Min, Malik, Asrar B
Format: Article
Language:English
Subjects:
Cardiovascular System - embryology
Cell Differentiation - physiology
Endothelium, Vascular - cytology
Endothelium, Vascular - physiology
Humans
Neovascularization, Physiologic - physiology
Signal Transduction - physiology
Transcription Factors - physiology
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Summary:The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the pathogenesis of vascular diseases. Here, we review the underlying molecular mechanisms of endothelial cell differentiation, plasticity, and the development of the vasculature. This review focuses on the interplay among transcription factors and signaling molecules that specify the differentiation of vascular endothelial cells. We also discuss recent progress on reprogramming of somatic cells toward distinct endothelial cell lineages and its promise in regenerative vascular medicine.
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.113.301078