Primary intracranial yolk sac tumor in the posterior fossa: Case report of a child with Down syndrome

Satge et al. summarized 38 central nervous system tumors in DS and reported that 14 (61%) of 23 cases under age 15 were germ cell tumors [3]. Robertson et al. reported the multimodal "sandwich" therapy, a course of PE (cisplatin and etoposide) therapy before radiation therapy and JEB proto...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2013-06, Vol.115 (6), p.811-813
Main Authors: Endo, Shogo, Kobayashi, Hiroyuki, Terasaka, Shunsuke, Iguchi, Akihiro, Cho, Yuko, Ohshima, Junjiro, Kubota, Kanako, Houkin, Kiyohiro
Format: Article
Language:English
Subjects:
Brain cancer
Chemoradiotherapy
Child, Preschool
Children & youth
Chromosomes
Combined Modality Therapy
Cranial Fossa, Posterior - pathology
Down syndrome
Down Syndrome - complications
Endodermal Sinus Tumor - pathology
Endodermal Sinus Tumor - therapy
Fetal Proteins - blood
Germ cell tumor
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Male
Neurology
Neurosurgery
Neurosurgical Procedures
Posterior fossa
Radiation therapy
Skull Base Neoplasms - pathology
Skull Base Neoplasms - therapy
Tumors
Yolk sac tumor
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Summary:Satge et al. summarized 38 central nervous system tumors in DS and reported that 14 (61%) of 23 cases under age 15 were germ cell tumors [3]. Robertson et al. reported the multimodal "sandwich" therapy, a course of PE (cisplatin and etoposide) therapy before radiation therapy and JEB protocol (etoposide, carboplatin, bleomycin) after radiation therapy, to malignant GCTs resulted in 4-year actuarial event-free and total survival rates of 67 and 74%, respectively.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2012.07.023