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Evaluation of pesticide-induced oxidative stress from a gene–environment interaction perspective
Highlights ► Long-term pesticide exposure decreased CAT activity. ► AChE showed a significant positive association with ALA-D and CAT. ► Only CAT activity was significantly associated with PON1 polymorphisms. ► GSTT1 polymorphism and BCHE variants significantly contributed to ALA-D and SOD. ► Signif...
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Published in: | Toxicology (Amsterdam) 2013-05, Vol.307, p.95-102 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights ► Long-term pesticide exposure decreased CAT activity. ► AChE showed a significant positive association with ALA-D and CAT. ► Only CAT activity was significantly associated with PON1 polymorphisms. ► GSTT1 polymorphism and BCHE variants significantly contributed to ALA-D and SOD. ► Significant gene–environment interactions were observed on antioxidant enzymes. |
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ISSN: | 0300-483X 1879-3185 |
DOI: | 10.1016/j.tox.2012.09.007 |