Loading…

Evaluation of pesticide-induced oxidative stress from a gene–environment interaction perspective

Highlights ► Long-term pesticide exposure decreased CAT activity. ► AChE showed a significant positive association with ALA-D and CAT. ► Only CAT activity was significantly associated with PON1 polymorphisms. ► GSTT1 polymorphism and BCHE variants significantly contributed to ALA-D and SOD. ► Signif...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology (Amsterdam) 2013-05, Vol.307, p.95-102
Main Authors: Hernández, Antonio F, Lacasaña, Marina, Gil, Fernando, Rodríguez-Barranco, Miguel, Pla, Antonio, López-Guarnido, Olga
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Long-term pesticide exposure decreased CAT activity. ► AChE showed a significant positive association with ALA-D and CAT. ► Only CAT activity was significantly associated with PON1 polymorphisms. ► GSTT1 polymorphism and BCHE variants significantly contributed to ALA-D and SOD. ► Significant gene–environment interactions were observed on antioxidant enzymes.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2012.09.007