Changes in male hormone profile after occupational organophosphate exposure. A longitudinal study

Highlights ► Long-term organophosphate (OP) pesticide exposure impacts on the endocrine system. ► The effect of OP exposure on male sex hormones was evaluated in Mexican floriculture workers. ► Urinary DAP concentrations were associated with increased serum FSH and prolactin. ► Urine DAP concentrati...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2013-05, Vol.307, p.55-65
Main Authors: Aguilar-Garduño, C, Lacasaña, M, Blanco-Muñoz, J, Rodríguez-Barranco, M, Hernández, A.F, Bassol, S, González-Alzaga, B, Cebrián, M.E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Agriculture
Aryldialkylphosphatase - metabolism
biomarkers
blood serum
DDT (pesticide)
Dichlorodiphenyl Dichloroethylene - blood
Emergency
Endocrine disrupting chemicals
Endocrine system
enzyme activity
epidemiological studies
equations
estradiol
Estradiol - blood
floriculture
Follicle Stimulating Hormone - blood
follicle-stimulating hormone
Gonadal Hormones - blood
Humans
inhibin
Inhibins - blood
laboratory animals
long term effects
Longitudinal Studies
luteinizing hormone
Luteinizing Hormone - blood
malaria
Male
metabolites
Middle Aged
Occupational Exposure - adverse effects
Occupational health
Organophosphate Poisoning - blood
Organophosphate Poisoning - complications
Organophosphorus Compounds - adverse effects
Organophosphorus Compounds - urine
Pesticides
Pesticides - adverse effects
pests
prolactin
Prolactin - blood
Sex hormones
Surveys and Questionnaires
testosterone
Testosterone - blood
toxicology
Young Adult
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Summary:Highlights ► Long-term organophosphate (OP) pesticide exposure impacts on the endocrine system. ► The effect of OP exposure on male sex hormones was evaluated in Mexican floriculture workers. ► Urinary DAP concentrations were associated with increased serum FSH and prolactin. ► Urine DAP concentrations were associated with decreased testosterone and inhibin B.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2012.11.001