Low-level laser therapy improves the inflammatory profile of rats with heart failure

Following heart failure (HF), immune activation leads to an imbalance between pro-inflammatory and anti-inflammatory cytokines. Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions. However, the effect of LLLT on the skeletal muscle of rats wit...

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Bibliographic Details
Published in:Lasers in medical science 2013-05, Vol.28 (3), p.1007-1016
Main Authors: Hentschke, Vítor S., Jaenisch, Rodrigo B., Schmeing, Letiane A., Cavinato, Paulo R., Xavier, Leder L., Dal Lago, Pedro
Format: Article
Language:English
Subjects:
Animals
Cytokines
Dentistry
Heart failure
Heart Failure - etiology
Heart Failure - immunology
Heart Failure - radiotherapy
Inflammation - etiology
Inflammation - immunology
Inflammation - radiotherapy
Inflammation Mediators - blood
Inflammation Mediators - metabolism
Interleukin-10 - blood
Interleukin-10 - metabolism
Interleukin-6 - blood
Interleukin-6 - metabolism
Lasers
Low-Level Light Therapy
Male
Medicine
Medicine & Public Health
Muscle, Skeletal - immunology
Muscle, Skeletal - radiation effects
Myocardial Infarction - complications
Optical Devices
Optics
Original Article
Photonics
Quantum Optics
Rats
Rats, Wistar
Rodents
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - metabolism
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Summary:Following heart failure (HF), immune activation leads to an imbalance between pro-inflammatory and anti-inflammatory cytokines. Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions. However, the effect of LLLT on the skeletal muscle of rats with HF remains unclear. The present report aimed to evaluate the influence of LLLT on the inflammatory profile of rats with HF. The left coronary artery was ligated to induce HF and a sham operation was performed in the control groups. Male Wistar rats ( n  = 49) were assigned to one of six groups: placebo sham rats (P-Sham; n  = 8), LLLT at a dose of 3 J/cm 2 sham rats (3 J/cm 2 -Sham; n  = 8), LLLT at a dose of 21 J/cm 2 sham rats (21 J/cm 2 -Sham; n  = 8), placebo HF rats (P-HF; n  = 9), LLLT at a dose of 3 J/cm 2 HF rats (3 J/cm 2 -HF; n  = 8), and LLLT at a dose of 21 J/cm 2 HF rats (21 J/cm 2 -HF; n  = 8). Four weeks after myocardial infarction or sham surgery, rats were subjected to LLLT (InGaAlP 660 nm, spot size 0.035 cm 2 , output power 20 mW, power density 0.571 W/cm 2 , energy density 3 or 21 J/cm 2 , exposure time 5.25 s and 36.75 s) on the right gastrocnemius for 10 consecutive days. LLLT reduced plasma IL-6 levels (61.3 %; P  
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-012-1190-4