Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice

• Published in: Journal of bioscience and bioengineering 2013-05, Vol.115 (5), p.547-551
• Main Authors: Ueki, Masaaki, Ueno, Masaki, Morishita, Jun, Maekawa, Nobuhiro
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - metabolism; Acute Kidney Injury - prevention & control; adhesion; Animals; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antineoplastic Agents - toxicity; antioxidant activity; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Biological and medical sciences; Biotechnology; blood serum; body weight; chemoattractants; Chemokine CCL2 - metabolism; Chemokines; Cisplatin; Cisplatin - toxicity; Curcumin; Curcumin - pharmacology; Curcumin - therapeutic use; curry; Fundamental and applied biological sciences. Psychology; gene expression; inflammation; Inflammation - drug therapy; Intercellular Adhesion Molecule-1 - genetics; Intercellular Adhesion Molecule-1 - metabolism; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; kidneys; Male; messenger RNA; Mice; Mice, Inbred C57BL; monocytes; necrosis; Nephrotoxicity; pathogenesis; polyphenols; protective effect; renal function; Tumor necrosis factor alpha; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 1389-1723; 1347-4421
• DOI: 10.1016/j.jbiosc.2012.11.007

Inflammatory mechanisms may play an important role in the pathogenesis of cisplatin-induced nephrotoxicity. Curcumin is an orange-yellow polyphenol present in curry spice and has anti-inflammatory and antioxidant effects. The purpose of this study was to determine the protective effects of curcumin on cisplatin-induced nephrotoxicity. Mice were randomly divided into four groups: control, cisplatin, cisplatin + curcumin and curcumin. Mice were given cisplatin (20 mg/kg body weight, intraperitoneally) with or without curcumin treatment (100 mg/kg body weight, intraperitoneally, immediately after cisplatin injection). Serum and renal tumor necrosis factor (TNF)-alpha and renal monocyte chemoattractant protein (MCP)-1 concentrations, intercellular adhesion molecule-1 (ICAM-1) mRNA expression in kidney, renal function and histological changes were determined 72 h after cisplatin injection. Serum TNF-alpha concentration in the cisplatin + curcumin group significantly decreased compared with that in the cisplatin group. Renal TNF-alpha and MCP-1 concentrations and ICAM-1 mRNA expression in kidney in the cisplatin + curcumin group also significantly decreased compared with those in the cisplatin group. Consequently, cisplatin-induced renal dysfunction and renal tubular necrosis scores were attenuated by curcumin treatment. These results indicate that curcumin acts to reduce cisplatin-induced nephrotoxicity through its anti-inflammatory effects. Thus, curcumin may become a new therapeutic candidate for the treatment of cisplatin-induced nephrotoxicity.