Determination of the role of calcium on instability of neurotoxic metabolite of ecstasy by HPTLC-mass

Ecstasy is one of the popular illicit drugs in the world and its usage has been recently increased in Iran. This compound can destroy the serotonergic neurons and produces cognitive and psychopathology diseases. 3,4-dihydroxymethamphetamine (HHMA), which is the main metabolite of this compound, seem...

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Published in:Daru 2013-01, Vol.21 (1), p.1-1
Main Authors: Jamali, Bardia, Ardakani, Yalda Hosseinzadeh, Rouini, Mohammad-Reza, oumadi, Alireza, Amidi, Salimeh, Zadeh Aghdam, Vahid Hossein, Kobarfard, Farzad
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Language:English
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Apoptosis
Calcium
Chromatography
Dopamine
Metabolites
Neurotoxicity
Serotonin
Software
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container_title Daru
container_volume 21
creator Jamali, Bardia
Ardakani, Yalda Hosseinzadeh
Rouini, Mohammad-Reza
oumadi, Alireza
Amidi, Salimeh
Zadeh Aghdam, Vahid Hossein
Kobarfard, Farzad
description Ecstasy is one of the popular illicit drugs in the world and its usage has been recently increased in Iran. This compound can destroy the serotonergic neurons and produces cognitive and psychopathology diseases. 3,4-dihydroxymethamphetamine (HHMA), which is the main metabolite of this compound, seems to be responsible for this effect. In this study, the stability of this crucial metabolite of ecstasy was examined in different mediums. The stability of HHMA was studied in the perfusion medium and water at 100 and 10 ng/mL concentrations. Moreover, the effect of temperature (0-25 degrees C), pH (3-10), calcium chloride (0-150 g/L) and ethylenediaminetetraacetic acid (EDTA) on the stability of HHMA was also examined. The result suggested that the free form of HHMA could be degraded in the perfusion medium. The rate of this degradation has direct proportion to temperature (at 25 degrees C = 0.037 min^sup -1^ and at 0 degree C = 0.002 min^sup -1^). Although, while degradation was prevented at pH=3, EDTA could only reduce this rate about 30%.
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subjects Apoptosis
Calcium
Chromatography
Dopamine
Metabolites
Neurotoxicity
Serotonin
Software
title Determination of the role of calcium on instability of neurotoxic metabolite of ecstasy by HPTLC-mass
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