Microsatellite variation in the equine MHC

Summary Genes within the major histocompatibility complex (MHC) encode proteins involved in innate and adaptive immune responses. Genetic variation in this region can influence the immune response of an individual animal to challenges from a variety of pathogens; however, a complete documentation of...

Full description

Saved in:
Bibliographic Details
Published in:Animal genetics 2013-06, Vol.44 (3), p.267-275
Main Authors: Brinkmeyer-Langford, C. L., Cai, J. J., Gill, C. A., Skow, L. C.
Format: Article
Language:English
Subjects:
Animals
Genetic Markers
Haplotypes
horse
Horses - genetics
Immune system
Linkage Disequilibrium
major histocompatibility complex
Major Histocompatibility Complex - genetics
Medical research
Microsatellite Repeats
polymorphism
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Genes within the major histocompatibility complex (MHC) encode proteins involved in innate and adaptive immune responses. Genetic variation in this region can influence the immune response of an individual animal to challenges from a variety of pathogens; however, a complete documentation of genetic variation in the MHC is lacking for most domestic animals, including horses. To provide additional genetic markers for study of the horse MHC, or ELA (equine lymphocyte antigen), we identified 37 polymorphic microsatellite repeats in ELA and used these variations separately and together with published SNPs to investigate linkage disequilibrium (LD) and haplotype structure in a sample of Thoroughbred horses. ELA SNPs alone detected little LD, but microsatellites, either separately or combined with SNPs, revealed substantially more LD. A subset of markers in very high LD across the breadth of ELA may be predictive of structural polymorphisms or linked epistases that are important drivers of haplotype structure in Thoroughbreds.
ISSN:0268-9146
1365-2052
DOI:10.1111/age.12003