Expression of parodontal tissue matrix metalloproteinases-1,2 in adolescent and their role in gingival pathology

Expression of matrix mettaloproteinases-1,2 were determine immunohistochemistry in gingival mucosa cells in Adolescent groups aged 9-13 and 14-17 years. The material was collected in cohort group of 50 persons. Relative data base - stomatological status in 618 school children aged 9-17 years (304 gi...

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Bibliographic Details
Published in:Georgian medical news 2013-04 (217), p.34-40
Main Author: Khimshiashvili, N B
Format: Article
Language:Russian
Subjects:
Adolescent
Age Factors
Child
Epithelial Cells - metabolism
Female
Gene Expression Regulation
Gingiva - metabolism
Gingiva - pathology
Gingival Crevicular Fluid - metabolism
Gingivitis - genetics
Gingivitis - metabolism
Gingivitis - pathology
Humans
Macrophages - metabolism
Male
Matrix Metalloproteinase 1 - biosynthesis
Matrix Metalloproteinase 2 - biosynthesis
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Summary:Expression of matrix mettaloproteinases-1,2 were determine immunohistochemistry in gingival mucosa cells in Adolescent groups aged 9-13 and 14-17 years. The material was collected in cohort group of 50 persons. Relative data base - stomatological status in 618 school children aged 9-17 years (304 girls and 314 boys). The MMP-1,2 levels were statistically higher in epitheliocytes, macrophages and capillaries endotheliocytes in all instances not depend on the sex and correlate with mucosa disease activity. It was found that MMP-1,2 expression were higher in prepubertal group. Activity of MMP-1, 2 in gingival mucosa was significantly elevated in female 14-17 years group, than those associated with group 9-13 years.
ISSN:1512-0112