Collagen hemostat significantly reduces time to hemostasis compared with cellulose: COBBANA, a single-center, randomized trial

Abstract Background This single-center, randomized trial compares the hemostatic effectiveness of microfibrillar collagen and oxidized cellulose in arterial bypass surgery. Methods In patients undergoing arterial bypass surgery, 2 hemostats, microfibrillar collagen and oxidized cellulose, were rando...

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Published in:The American journal of surgery 2013-06, Vol.205 (6), p.636-641
Main Authors: Qerimi, Bekim, Baumann, Petra, Ph.D, Hüsing, Johannes, Ph.D, Knaebel, Hanns-Peter, M.D, Schumacher, Hardy, M.D
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anastomosis, Surgical
Blood Vessel Prosthesis Implantation
Body mass index
Cellulose
Cellulose, Oxidized
Collagen
Female
Heart surgery
Hemostasis
Hemostasis, Surgical
Hemostatics
Humans
Likert scale
Male
Middle Aged
Mortality
Peripheral Vascular Diseases - surgery
Polytetrafluoroethylene
Prostheses
Studies
Surgery
Suture hole bleeding
Time Factors
Topical hemostatic agent
Wound healing
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Summary:Abstract Background This single-center, randomized trial compares the hemostatic effectiveness of microfibrillar collagen and oxidized cellulose in arterial bypass surgery. Methods In patients undergoing arterial bypass surgery, 2 hemostats, microfibrillar collagen and oxidized cellulose, were randomly used to achieve hemostasis. The primary endpoint was the time to hemostasis. The secondary endpoints were the complication rate, mortality, number of hemostats required, handling, and adhesion. Results Collagen achieved hemostasis significantly faster than cellulose, with considerably less hemostats. In addition, its ease of use was rated substantially better. Conclusion In arterial bypass surgery, microfibrillar collagen is more effective than oxidized cellulose in achieving hemostasis.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2012.05.033