The value of serum asymmetric dimethylarginine levels for the determination of masked hypertension in patients with diabetes mellitus

Abstract Background An increased prevalence of masked hypertension (MHT) has been demonstrated among patients with diabetes mellitus (DM). MHT appears to cause cardiovascular (CV) complications similar to clinically overt hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide...

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Bibliographic Details
Published in:Atherosclerosis 2013-06, Vol.228 (2), p.432-437
Main Authors: Taner, Alpaslan, Unlu, Ali, Kayrak, Mehmet, Tekinalp, Mehmet, Ayhan, Selim S, Arbaş, Alpay, Erdem, Said Sami
Format: Article
Language:English
Subjects:
ADMA
Adult
arginine
Arginine - analogs & derivatives
Arginine - blood
atherosclerosis
Biomarkers - blood
Blood pressure
Blood Pressure Monitoring, Ambulatory
blood serum
body mass index
Cardiovascular
Chi-Square Distribution
Chromatography, High Pressure Liquid
Cross-Sectional Studies
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Female
Fluorescence
high density lipoprotein
high performance liquid chromatography
Humans
hypertension
Hypertension - blood
Hypertension - diagnosis
Hypertension - epidemiology
Logistic Models
Male
Masked hypertension
Middle Aged
Multivariate Analysis
nitric oxide
Odds Ratio
pathophysiology
patients
Predictive Value of Tests
Prevalence
regression analysis
risk
Risk Factors
screening
Turkey - epidemiology
Type 2
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Summary:Abstract Background An increased prevalence of masked hypertension (MHT) has been demonstrated among patients with diabetes mellitus (DM). MHT appears to cause cardiovascular (CV) complications similar to clinically overt hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased CV risk in both the general population and among patients with DM. The aim of this study was to evaluate the relationship between MHT and ADMA in diabetic patients. Methods This study included DM patients ( n  = 131) with normal office blood pressure (
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2013.02.024