Anti-IFI16 antibodies and their relation to disease characteristics in systemic lupus erythematosus

Objective Several studies have shown the presence of anti-IFI16 antibodies in systemic lupus erythematosus (SLE), Sjögren Syndrome (SjS), systemic sclerosis (SSc) and other autoimmune diseases. However, the significance of anti-IFI16 antibodies in SLE has not been fully characterized. The aim of thi...

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Bibliographic Details
Published in:Lupus 2013-05, Vol.22 (6), p.607-613
Main Authors: Caneparo, V, Cena, T, De Andrea, M, Dell'Oste, V, Stratta, P, Quaglia, M, Tincani, A, Andreoli, L, Ceffa, S, Taraborelli, M, Magnani, C, Landolfo, S, Gariglio, M
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies
Antibodies, Antinuclear - immunology
Autoimmune diseases
Case-Control Studies
Complement C3 - deficiency
Disease
Enzyme-Linked Immunosorbent Assay
Enzymes
Female
Glomerulonephritis - immunology
Health care
Hospitals
Humans
Inflammation - etiology
Inflammation - immunology
Lupus
Lupus Erythematosus, Systemic - immunology
Male
Medical schools
Middle Aged
Multivariate Analysis
Nuclear Proteins - immunology
Phosphoproteins - immunology
Proteinuria - etiology
Proteinuria - immunology
Scleroderma
Serology
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Summary:Objective Several studies have shown the presence of anti-IFI16 antibodies in systemic lupus erythematosus (SLE), Sjögren Syndrome (SjS), systemic sclerosis (SSc) and other autoimmune diseases. However, the significance of anti-IFI16 antibodies in SLE has not been fully characterized. The aim of this study was to investigate associations between anti-IFI16 antibodies and clinical and serologic parameters of SLE. Methods An enzyme-linked immunosorbent assay (ELISA) kit was used to measure anti-IFI16 antibodies in the sera of 168 SLE patients, 46 patients with any type of primary glomerulonephritis (GN) and 182 healthy controls (HCs). Associations between anti-IFI16 antibodies and clinical and serologic parameters of SLE were statistically evaluated using both univariate and multivariate analysis. Results Significantly higher anti-IFI16 titres were observed in SLE patients compared to both non-SLE GN and HCs (median levels: 270.1 U/ml vs 132.1 U/ml, p = 0.001, and 52.9 U/ml, p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203313484978