Tumor promoting activity of 1,8-dihydroxy-3-methyl-9-anthrone (chrysarobin) in female SENCAR mice

Purified 1,8-dihydroxy-3-methyl-9-anthrone or chrysarobin was found to be an effective skin tumor-promoter in SENCAR mice, although, at the dose used, it was ˜43-fold less active than 12-O-tradecanoylphorbol-13-acetate (TPA). When non-promoting doses of chrysarobin were applied 30 min prior to each...

Full description

Saved in:
Bibliographic Details
Published in:Carcinogenesis (New York) 1983, Vol.4 (3), p.281-284
Main Authors: DiGiovanni, J., Boutwell, R.K.
Format: Article
Language:English
Subjects:
Animals
Anthracenes - toxicity
Carcinogens - toxicity
Female
Mice
Mice, Inbred Strains
Neoplasms, Experimental - pathology
Papilloma - chemically induced
Papilloma - pathology
Skin Neoplasms - chemically induced
Skin Neoplasms - pathology
Tetradecanoylphorbol Acetate
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purified 1,8-dihydroxy-3-methyl-9-anthrone or chrysarobin was found to be an effective skin tumor-promoter in SENCAR mice, although, at the dose used, it was ˜43-fold less active than 12-O-tradecanoylphorbol-13-acetate (TPA). When non-promoting doses of chrysarobin were applied 30 min prior to each application of TPA, a marked potentiation in the promoting response to TPA was observed. Chrysarobin will provide a valuable tool for studying the mechanism of action of anthracene-derived mouse skin tumor promoters.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/4.3.281