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Glutathione S-transferase P1 Ile105Val polymorphism contributes to increased risk of gastric cancer in East Asians
Glutathione S-transferase P1 (GSTP1) is an important enzyme playing critical roles in the phase II detoxification pathway. There were many studies investigating the association between GSTP1 gene Ile105Val polymorphism and gastric cancer risk, but studies from East Asians reported inconsistent findi...
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| Published in: | Tumor biology 2013-06, Vol.34 (3), p.1737-1742 |
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| creator | Ma, Yanjuan Wei, Xiaoxia Han, Guangye Xue, Minghui Li, Guangyan Li, Yan |
| description | Glutathione S-transferase P1 (GSTP1) is an important enzyme playing critical roles in the phase II detoxification pathway. There were many studies investigating the association between GSTP1 gene Ile105Val polymorphism and gastric cancer risk, but studies from East Asians reported inconsistent findings. We performed a meta-analysis to investigate the association in East Asians. Published literature from PubMed and Chinese Biomedical Literature databases were searched for eligible publications. Pooled odds ratios (ORs) with 95 % confidence intervals (95 %CIs) were calculated using random or fixed-effect model according the between-study heterogeneity. A total of 12 studies with 2,552 cases and 5,474 controls were finally included into the meta-analysis. Meta-analysis of those 12 studies showed that there was an obvious association between GSTP1 Ile105Val polymorphism and gastric cancer risk in East Asians under three genetic models (for valine vs. isoleucine, OR = 1.32, 95 %CI 1.05–1.66,
P
= 0.015; for ValVal vs. IleIle, OR = 2.00, 95 %CI 1.34–2.98,
P
= 0.001; for the recessive model, OR = 1.96, 95 %CI 1.35–2.83,
P
|
| doi_str_mv | 10.1007/s13277-013-0711-5 |
| format | article |
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P
= 0.015; for ValVal vs. IleIle, OR = 2.00, 95 %CI 1.34–2.98,
P
= 0.001; for the recessive model, OR = 1.96, 95 %CI 1.35–2.83,
P
< 0.001). Sensitivity analysis by removing one study at a time suggested the pooled results were stable under the three genetic models above. There was no risk of publication bias. In conclusion, the meta-analysis suggests that there is a strong evidence for the association between GSTP1 Ile105Val polymorphism and increased risk of gastric cancer in East Asians and contributes to increased risk of gastric cancer in East Asians.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-013-0711-5</identifier><identifier>PMID: 23456768</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Case-Control Studies ; Far East - epidemiology ; Gastric cancer ; Genes ; Genetic Predisposition to Disease ; Glutathione S-Transferase pi - genetics ; Humans ; Meta-analysis ; Polymorphism ; Polymorphism, Genetic - genetics ; Research Article ; Risk Factors ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - etiology</subject><ispartof>Tumor biology, 2013-06, Vol.34 (3), p.1737-1742</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-7e89743e0afd88772771d6a20f9297d6a6ca8d781833fb41125ea682a2cd76933</citedby><cites>FETCH-LOGICAL-c372t-7e89743e0afd88772771d6a20f9297d6a6ca8d781833fb41125ea682a2cd76933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1353939860?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23456768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Yanjuan</creatorcontrib><creatorcontrib>Wei, Xiaoxia</creatorcontrib><creatorcontrib>Han, Guangye</creatorcontrib><creatorcontrib>Xue, Minghui</creatorcontrib><creatorcontrib>Li, Guangyan</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><title>Glutathione S-transferase P1 Ile105Val polymorphism contributes to increased risk of gastric cancer in East Asians</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>Glutathione S-transferase P1 (GSTP1) is an important enzyme playing critical roles in the phase II detoxification pathway. There were many studies investigating the association between GSTP1 gene Ile105Val polymorphism and gastric cancer risk, but studies from East Asians reported inconsistent findings. We performed a meta-analysis to investigate the association in East Asians. Published literature from PubMed and Chinese Biomedical Literature databases were searched for eligible publications. Pooled odds ratios (ORs) with 95 % confidence intervals (95 %CIs) were calculated using random or fixed-effect model according the between-study heterogeneity. A total of 12 studies with 2,552 cases and 5,474 controls were finally included into the meta-analysis. Meta-analysis of those 12 studies showed that there was an obvious association between GSTP1 Ile105Val polymorphism and gastric cancer risk in East Asians under three genetic models (for valine vs. isoleucine, OR = 1.32, 95 %CI 1.05–1.66,
P
= 0.015; for ValVal vs. IleIle, OR = 2.00, 95 %CI 1.34–2.98,
P
= 0.001; for the recessive model, OR = 1.96, 95 %CI 1.35–2.83,
P
< 0.001). Sensitivity analysis by removing one study at a time suggested the pooled results were stable under the three genetic models above. There was no risk of publication bias. In conclusion, the meta-analysis suggests that there is a strong evidence for the association between GSTP1 Ile105Val polymorphism and increased risk of gastric cancer in East Asians and contributes to increased risk of gastric cancer in East Asians.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Far East - epidemiology</subject><subject>Gastric cancer</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Glutathione S-Transferase pi - genetics</subject><subject>Humans</subject><subject>Meta-analysis</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Research Article</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach Neoplasms - etiology</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kUFP3DAQhS1UBFvKD-ilstQLl1CPncT2Ea1gQUICCejV8joTCE3irSc58O_r1S5VhdTTzNjfe2PrMfYVxDkIoX8QKKl1IUAVQgMU1QFbQCnzpIz4lHsBoiilUcfsM9GrEFBZWx-xY6nKqta1WbC06ufJTy9dHJE_FFPyI7WYPCG_B37TI4jqp-_5JvZvQ0ybl44GHuI4pW49T0h8irwbQ8KsaHjq6BePLX_2lIHAgx8Dpgzwy3zCL6jL9l_YYet7wtN9PWFPV5ePy-vi9m51s7y4LYLScio0GqtLhcK3jTFa559CU3spWiutzl0dvGm0AaNUuy4BZIW-NtLL0OjaKnXCzna-mxR_z0iTGzoK2Pd-xDiTA1VVpdba2Ix-_4C-xjmN-XVbSlllTS0yBTsqpEiUsHWb1A0-vTkQbhuI2wXiciBuG4irsubb3nleD9j8VbwnkAG5Ayhfjc-Y_ln9X9c_oMSU9A</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Ma, Yanjuan</creator><creator>Wei, Xiaoxia</creator><creator>Han, Guangye</creator><creator>Xue, Minghui</creator><creator>Li, Guangyan</creator><creator>Li, Yan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Glutathione S-transferase P1 Ile105Val polymorphism contributes to increased risk of gastric cancer in East Asians</title><author>Ma, Yanjuan ; Wei, Xiaoxia ; Han, Guangye ; Xue, Minghui ; Li, Guangyan ; Li, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-7e89743e0afd88772771d6a20f9297d6a6ca8d781833fb41125ea682a2cd76933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Far East - epidemiology</topic><topic>Gastric cancer</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Glutathione S-Transferase pi - genetics</topic><topic>Humans</topic><topic>Meta-analysis</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Research Article</topic><topic>Risk Factors</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach Neoplasms - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Yanjuan</creatorcontrib><creatorcontrib>Wei, Xiaoxia</creatorcontrib><creatorcontrib>Han, Guangye</creatorcontrib><creatorcontrib>Xue, Minghui</creatorcontrib><creatorcontrib>Li, Guangyan</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Yanjuan</au><au>Wei, Xiaoxia</au><au>Han, Guangye</au><au>Xue, Minghui</au><au>Li, Guangyan</au><au>Li, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione S-transferase P1 Ile105Val polymorphism contributes to increased risk of gastric cancer in East Asians</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>34</volume><issue>3</issue><spage>1737</spage><epage>1742</epage><pages>1737-1742</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>Glutathione S-transferase P1 (GSTP1) is an important enzyme playing critical roles in the phase II detoxification pathway. There were many studies investigating the association between GSTP1 gene Ile105Val polymorphism and gastric cancer risk, but studies from East Asians reported inconsistent findings. We performed a meta-analysis to investigate the association in East Asians. Published literature from PubMed and Chinese Biomedical Literature databases were searched for eligible publications. Pooled odds ratios (ORs) with 95 % confidence intervals (95 %CIs) were calculated using random or fixed-effect model according the between-study heterogeneity. A total of 12 studies with 2,552 cases and 5,474 controls were finally included into the meta-analysis. Meta-analysis of those 12 studies showed that there was an obvious association between GSTP1 Ile105Val polymorphism and gastric cancer risk in East Asians under three genetic models (for valine vs. isoleucine, OR = 1.32, 95 %CI 1.05–1.66,
P
= 0.015; for ValVal vs. IleIle, OR = 2.00, 95 %CI 1.34–2.98,
P
= 0.001; for the recessive model, OR = 1.96, 95 %CI 1.35–2.83,
P
< 0.001). Sensitivity analysis by removing one study at a time suggested the pooled results were stable under the three genetic models above. There was no risk of publication bias. In conclusion, the meta-analysis suggests that there is a strong evidence for the association between GSTP1 Ile105Val polymorphism and increased risk of gastric cancer in East Asians and contributes to increased risk of gastric cancer in East Asians.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>23456768</pmid><doi>10.1007/s13277-013-0711-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Far East - epidemiology Gastric cancer Genes Genetic Predisposition to Disease Glutathione S-Transferase pi - genetics Humans Meta-analysis Polymorphism Polymorphism, Genetic - genetics Research Article Risk Factors Stomach Neoplasms - epidemiology Stomach Neoplasms - etiology |
| title | Glutathione S-transferase P1 Ile105Val polymorphism contributes to increased risk of gastric cancer in East Asians |
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