[Fe]-Hydrogenase and Models that Contain IronAcyl Ligation

[Fe]‐hydrogenase is a newly characterized type of hydrogenase. This enzyme heterolytically splits hydrogen in the presence of a natural substrate. The active site of the enzyme contains a mono‐iron complex with intriguing ironacyl ligation. Several groups have recently developed ironacyl complexes...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2013-06, Vol.8 (6), p.1068-1075
Main Authors: Schultz, Katherine M., Chen, Dafa, Hu, Xile
Format: Article
Language:English
Subjects:
acyl ligands
Acylation
carbonyl ligands
Catalytic Domain
enzymes
hydrogenase
Hydrogenase - chemistry
iron
Iron - chemistry
Iron-Sulfur Proteins - chemistry
Ligands
Models, Molecular
X-Ray Absorption Spectroscopy
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Summary:[Fe]‐hydrogenase is a newly characterized type of hydrogenase. This enzyme heterolytically splits hydrogen in the presence of a natural substrate. The active site of the enzyme contains a mono‐iron complex with intriguing ironacyl ligation. Several groups have recently developed ironacyl complexes as synthetic models of [Fe]‐hydrogenase. This Focus Review summarizes the studies of this enzyme and its model compounds, with an emphasis on our own research in this area. Plenty of [Fe]s in the fire: Recent studies on the structure and properties of [Fe]‐hydrogenase have revealed the presence of a mono‐iron‐containing active site with ironacyl ligation. A number of synthetic complexes with this type of ligation have been prepared as models of this active site.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201300232