Amaranth Oil Increased Fecal Excretion of Bile Acid but Had No Effect in Reducing Plasma Cholesterol in Hamsters

Hamsters were fed for 4 weeks on four different diets: control (C) (balanced diet containing 20 % corn oil as the lipid source), hypercholesterolemic (H) (identical to C but containing 12 % coconut oil, 8 % corn oil and 0.1 % cholesterol as the lipid source), amaranth oil (A) (identical to H without...

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Bibliographic Details
Published in:Lipids 2013-06, Vol.48 (6), p.609-618
Main Authors: de Castro, Luíla Ívini Andrade, Soares, Rosana Aparecida Manólio, Saldiva, Paulo H. N., Ferrari, Roseli A., Miguel, Ana M. R. O., Almeida, Claudia A. S., Arêas, José Alfredo Gomes
Format: Article
Language:English
Subjects:
Amaranth
Amaranthus - chemistry
Animals
Bile Acids and Salts - analysis
Bile Acids and Salts - metabolism
Biomedical and Life Sciences
Cholesterol
Cholesterol - blood
Cholesterol - metabolism
Coconut oil
Corn
Cricetinae
Diet
Excretion
Feces - chemistry
Hamsters
Hypocholesterolemic diet
Life Sciences
Lipid metabolism
Lipidology
Lipids - blood
Liver - metabolism
Male
Medical Biochemistry
Medicinal Chemistry
Microbial Genetics and Genomics
Neurochemistry
Nutrition
Original Article
Plant Oils - pharmacology
Squalene
Vegetable oil
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Summary:Hamsters were fed for 4 weeks on four different diets: control (C) (balanced diet containing 20 % corn oil as the lipid source), hypercholesterolemic (H) (identical to C but containing 12 % coconut oil, 8 % corn oil and 0.1 % cholesterol as the lipid source), amaranth oil (A) (identical to H without corn oil but with amaranth oil), and squalene (S) (identical to H but admixed with squalene in the ratio found in amaranth oil). There were no significant differences in lipid profile, and in the cholesterol excreted in the animals’ feces from amaranth oil (A) and squalene (S) groups. Fecal excretion of bile acids was greater in the amaranth oil (A) and squalene groups (S) as compared to the other groups. The scores of steatosis and parenchymal inflammation observed in the amaranth oil (A) and squalene groups (S) were superior to the ones observed in the other groups. Our findings demonstrated that amaranth oil, and its component squalene, increased the excretion of bile acids but did not have a hypocholesterolemic effect in hamsters fed on a diet containing high amounts of saturated fat and cholesterol.
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-013-3772-8