Different ghrelin localisation in adult human and rat endocrine pancreas

Ghrelin is an endocrine peptide that has been identified in gastric oxyntic glands and that induces growth hormone secretion in the pituitary gland. This growth hormone secretagogue is expressed in many tissues such as stomach, pituitary gland, thyroid, testis, placenta and pancreas. Initial studies...

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Bibliographic Details
Published in:Cell and tissue research 2013-06, Vol.352 (3), p.487-494
Main Authors: Raghay, Kawtar, Gallego, Rosalia, Scoazec, Jean-Yves, Garcia-Caballero, Tomas, Morel, Gérard
Format: Article
Language:English
Subjects:
Adult
adults
Aged
Animals
Biomedical and Life Sciences
Biomedicine
Cellular biology
Dextrose
Fluorescent Antibody Technique
Gene Expression Regulation
ghrelin
Ghrelin - genetics
Ghrelin - metabolism
Glucose
Glucose metabolism
Growth hormones
homeostasis
hormone secretion
Human body
Human Genetics
Humans
immunohistochemistry
In Situ Hybridization
Islets of Langerhans - cytology
Islets of Langerhans - metabolism
Male
Middle Aged
Molecular Medicine
Pancreas
pituitary gland
placenta
Protein Transport
Proteomics
Rats
Rats, Wistar
Regular Article
Rodents
Somatotropin
stomach
testes
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Summary:Ghrelin is an endocrine peptide that has been identified in gastric oxyntic glands and that induces growth hormone secretion in the pituitary gland. This growth hormone secretagogue is expressed in many tissues such as stomach, pituitary gland, thyroid, testis, placenta and pancreas. Initial studies of ghrelin focused on its role as a circulating orexigenic signal. However, ghrelin has also been found to be involved in the modulation of glucose homeostasis. Although a number of studies have reported ghrelin expression in developing pancreas, the location of ghrelin-immunoreactive cells in adult pancreas (epsilon cells) remains controversial. In this study, we have analysed the distribution of pancreatic epsilon cells in adult human and rat islets by immunohistochemistry and in situ hybridisation. In humans, our immunohistochemical analysis has shown that ghrelin is expressed in glucagon-secreting cells, whereas in rats, it is present in insulin-secreting cells. Similar observations have been revealed by in situ hybridisation.
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-013-1593-y