Vesicle coats: structure, function, and general principles of assembly

The transport of proteins and lipids between distinct cellular compartments is conducted by coated vesicles. These vesicles are formed by the self-assembly of coat proteins on a membrane, leading to collection of the vesicle cargo and membrane bending to form a bud. Scission at the bud neck releases...

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Bibliographic Details
Published in:Trends in cell biology 2013-06, Vol.23 (6), p.279-288
Main Authors: Faini, Marco, Beck, Rainer, Wieland, Felix T, Briggs, John A.G
Format: Article
Language:English
Subjects:
assembly
clathrin
Clathrin - chemistry
Clathrin - metabolism
Coat Protein Complex I - chemistry
Coat Protein Complex I - metabolism
coated vesicles
Coated Vesicles - chemistry
Coated Vesicles - metabolism
COPI
COPII
Crystallography, X-Ray
GTP Phosphohydrolases - metabolism
Humans
Membrane Proteins - metabolism
Models, Molecular
Pathology
Protein Transport
structure
Vesicular Transport Proteins - metabolism
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Summary:The transport of proteins and lipids between distinct cellular compartments is conducted by coated vesicles. These vesicles are formed by the self-assembly of coat proteins on a membrane, leading to collection of the vesicle cargo and membrane bending to form a bud. Scission at the bud neck releases the vesicle. X-ray crystallography and electron microscopy (EM) have recently generated models of isolated coat components and assembled coats. Here, we review these data to present a structural overview of the three main coats: clathrin, COPII, and COPI. The three coats have similar function, common ancestry, and structural similarities, but exhibit fundamental differences in structure and assembly. We describe the implications of structural similarities and differences for understanding the function, assembly principles, and evolution of vesicle coats.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2013.01.005