New insights into the machinery of blood digestion by ticks

Highlights • Ticks digest blood intracellularly by a multi-enzyme system of cysteine and aspartic proteases. • A similar proteolytic machinery is employed by evolutionarily distant hematophagous parasites. • Tick digestive system offers new targeted strategies to control ticks and tick-borne disease...

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Bibliographic Details
Published in:Trends in parasitology 2013-06, Vol.29 (6), p.276-285
Main Authors: Sojka, Daniel, Franta, Zdeněk, Horn, Martin, Caffrey, Conor R, Mareš, Michael, Kopáček, Petr
Format: Article
Language:English
Subjects:
Animals
blood
Blood Proteins - metabolism
cathepsin
digestion
Digestion - physiology
digestive system
Gastroenterology and Hepatology
Gastrointestinal Tract - enzymology
hematophagy
hemoglobin
Infectious Disease
Ixodes
Nematoda
nutrients
parasitology
pathogens
peptidase
Plasmodium
Platyhelminthes
proteolysis
tick
ticks
Ticks - physiology
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Summary:Highlights • Ticks digest blood intracellularly by a multi-enzyme system of cysteine and aspartic proteases. • A similar proteolytic machinery is employed by evolutionarily distant hematophagous parasites. • Tick digestive system offers new targeted strategies to control ticks and tick-borne diseases.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2013.04.002