Is expression of p120ctn in oral squamous cell carcinomas a prognostic factor?

Objectives p120ctn is a component of the catenin family. To date, there have only been two studies examining expression levels of p120ctn in oral squamous cell carcinoma (OSCC). Materials and methods Paraffined specimens of 113 OSCCs and 12 of normal mucosa were examined by immunohistochemistry. Fro...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2013-06, Vol.115 (6), p.789-798
Main Authors: Lo Muzio, Lorenzo, MD, PhD, Pannone, Giuseppe, MD, DDS, Santarelli, Andrea, DDS, Bambini, Fabrizio, MD, Mascitti, Marco, DDS, Rubini, Corrado, MD, Testa, Nunzio F., MD, Dioguardi, Mario, DDS, Leuci, Stefania, DDS, PhD, Bascones, Antonio, MD, Reynolds, Albert B., PhD, Mariggiò, Maria Addolorata, MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Catenins - metabolism
Cell Line, Tumor
Dentistry
Female
Fluorescent Antibody Technique
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - mortality
Mouth Neoplasms - pathology
Prognosis
Retrospective Studies
Surgery
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Summary:Objectives p120ctn is a component of the catenin family. To date, there have only been two studies examining expression levels of p120ctn in oral squamous cell carcinoma (OSCC). Materials and methods Paraffined specimens of 113 OSCCs and 12 of normal mucosa were examined by immunohistochemistry. Frozen samples of 20 OSCCs and 5 of normal mucosa were examined by Western blot (WB). Results were correlated with clinicopathological parameters. Five cell lines were examined by immunofluorescence, immunocytochemistry, and WB to show immunoreactivity and cellular localization of p120ctn. Results Altered p120ctn expression was observed in 109/113 cases of OSCC. Heterogenous cytoplasmic/nuclear expression was associated with loss of membranous distribution (88/113 cases). Complete loss of expression was noted in 21/113 cases. Increased cytoplasmic expression was evident in all positive cases, without significant correlation among p120ctn staining/pattern and grading/stage. Reduction/absence of p120ctn expression was related to poor prognosis ( P  
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2013.03.006