An electrochemical biosensor for clenbuterol detection and pharmacokinetics investigation

Clenbuterol is a member of β2 adrenergic agonists, which is widely used not only as a food additive for livestocks, but also a kind of stimulant for athletes; however, the abuse of clenbuterol may pose a significant negative impact on human health. Since it is highly required to develop fast, sensit...

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Bibliographic Details
Published in:Talanta (Oxford) 2013-09, Vol.113, p.36-40
Main Authors: Bo, Bing, Zhu, Xuejun, Miao, Peng, Pei, Dong, Jiang, Bo, Lou, Yue, Shu, Yongqian, Li, Genxi
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - pharmacokinetics
Adrenergic beta-Agonists - urine
Animals
Biosensing Techniques
Biosensors
Clenbuterol
Clenbuterol - pharmacokinetics
Clenbuterol - urine
Electrochemical Techniques
Electrodes
Female
Food Contamination
Gold - chemistry
Metal Nanoparticles - chemistry
Nanoparticles
Performance-Enhancing Substances - pharmacokinetics
Performance-Enhancing Substances - urine
Pharmacokinetics
Platinum - chemistry
Rats
Rats, Sprague-Dawley
Substance Abuse Detection
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Summary:Clenbuterol is a member of β2 adrenergic agonists, which is widely used not only as a food additive for livestocks, but also a kind of stimulant for athletes; however, the abuse of clenbuterol may pose a significant negative impact on human health. Since it is highly required to develop fast, sensitive and cost-effective method to determine clenbuterol level in the suspected urine or blood, we herein have fabricated an electrochemical biosensor for the determination of clenbuterol. Measurement of the species with the proposed biosensor can also have the advantages of simplicity, high sensitivity and selectivity. Moreover, the sensor can be directly used for clenbuterol determination in rat urine. We have further studied the pharmacokinetics of clenbuterol by using this proposed electrochemical biosensor, so a new tool to investigate pharmacokinetic is developed in this work. [Display omitted] •A sensitive biosensor for clenbuterol is developed using platinum nanoparticles.•It can be used to unequivocally diagnose clenbuterol food poisoning.•It has potentials to develop next-generation strategies for pharmacokinetic study.
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2013.03.056