Sedation and paralysis

Sedation is used almost universally in the care of critically ill patients, especially in those who require mechanical ventilatory support or other life-saving invasive procedures. This review will focus on the sedation strategies for critically ill patients and the pharmacology of commonly used sed...

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Bibliographic Details
Published in:Respiratory care 2013-06, Vol.58 (6), p.1024-1037
Main Authors: Piriyapatsom, Annop, Bittner, Edward A, Hines, Jessica, Schmidt, Ulrich H
Format: Article
Language:English
Subjects:
Algorithms
Care and treatment
Critical Care
Critical Illness - therapy
Critically ill
Deep Sedation - adverse effects
Drug Monitoring
Health aspects
Humans
Hypnotics
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - adverse effects
Neuromuscular Blocking Agents - administration & dosage
Neuromuscular Blocking Agents - adverse effects
Paralysis
Paralysis - chemically induced
Patient outcomes
Physical therapy
Respiration, Artificial - methods
Respiratory insufficiency
Sedatives
Therapeutics, Physiological
Ventilator Weaning
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Description
Summary:Sedation is used almost universally in the care of critically ill patients, especially in those who require mechanical ventilatory support or other life-saving invasive procedures. This review will focus on the sedation strategies for critically ill patients and the pharmacology of commonly used sedative agents. The role of neuromuscular blocking agents in the ICU will be examined and the pharmacology of commonly used agents is reviewed. Finally a strategy for rational use of these sedative and neuromuscular blocking agents in critically ill patients will be proposed.
ISSN:0020-1324
1943-3654
DOI:10.4187/respcare.02232