Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit

Ziziphus mistol Griseb. (Rhamnaceae), popularly known as “mistol,” is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several Argentinean communities. The aim of this work is to quantify Z. mistol fruit macronutrients and phytochemical...

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Bibliographic Details
Published in:Food research international 2011-08, Vol.44 (7), p.2063-2071
Main Authors: Cardozo, M.L., Ordoñez, R.M., Alberto, M.R., Zampini, I.C., Isla, M.I.
Format: Article
Language:English
Subjects:
Alcoholic beverages
antioxidant activity
biodiversity
Biological activity
dose response
electrons
fruits
functional properties
gallic acid
Genotoxicity
hydrogen
hydroxyl radicals
lipoxygenase
maceration
mutagenicity
phytochemicals
polyphenols
Rhamnaceae
small fruits
Ziziphus
Ziziphus mistol
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Summary:Ziziphus mistol Griseb. (Rhamnaceae), popularly known as “mistol,” is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several Argentinean communities. The aim of this work is to quantify Z. mistol fruit macronutrients and phytochemicals as well as to determine its functional antioxidant and anti-inflammatory properties and toxicity after two different processes: boiling and hydroalcoholic extraction. Phytochemical recovery was variable depending on the extraction method used. All preparations showed antioxidant activity, but the ethanolic one (EME) was significantly more active than the aqueous one (AME) as hydrogen or electron donors with SC50 values between 1.45 to 6.31μgGAE/mL and 7.38 to 64.77μgGAE/mL, respectively. The aqueous extraction was significantly more active than EME on superoxide and hydroxyl radical scavenging. Polyphenols showed a dose–response relationship (R2>0.90) with antioxidant capacity in the decoction and the alcoholic beverage. The maceration showed an inhibitory effect on lipoxygenase (LOX) activity with an inhibitory concentration (IC50) value of 183.80μg gallic acid equivalents (GAE)/mL but the decoction did not. On the other hand, extracts did not show any mutagenic effect. Therefore, mistol fruits consumption could be encouraged not only for its functional properties, but also because of the positive ecological impact of preserving biological diversity through the exploitation of native natural resources in a regional economy.
ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2011.02.040