Dynamic Changes of FDG Uptake and Clearance in Normal Tissues

Purpose This study aims to evaluate dynamic 2-deoxy-2-[ 18 F]fluoro- d -glucose (FDG) uptake in normal tissues. Procedures Thirty male patients underwent FDG positron emission tomography (PET)/computed tomography imaging at 1, 2, and 3 h after tracer injection. Standardized uptake values (SUV) were...

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Bibliographic Details
Published in:Molecular imaging and biology 2013-06, Vol.15 (3), p.345-352
Main Authors: Cheng, Gang, Alavi, Abass, Lim, Esther, Werner, Thomas J., Del Bello, Catherine V., Akers, Scott R
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Heart - diagnostic imaging
Humans
Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Organ Specificity
Radiology
Radionuclide Imaging
Research Article
Time Factors
Tissue Distribution
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Summary:Purpose This study aims to evaluate dynamic 2-deoxy-2-[ 18 F]fluoro- d -glucose (FDG) uptake in normal tissues. Procedures Thirty male patients underwent FDG positron emission tomography (PET)/computed tomography imaging at 1, 2, and 3 h after tracer injection. Standardized uptake values (SUV) were obtained in regions of interest of normal tissues. Results The aorta (blood pool), liver, and spleen FDG activity demonstrated significantly and continuously decreased activity from 1 to 2 and 2 to 3 h, while FDG uptake in the lungs, pancreas, lymph nodes, and skeletal muscle decreased from 1 to 2 h only. In contrast, the left ventricular myocardium demonstrated two patterns of dynamic changes: myocardium with higher FDG uptake (SUV max  ≥ 3.25) on the initial images had more remarkable increased activity on the delayed images, while myocardium with lower FDG uptake (SUV max  
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-012-0600-0