Effects of two bacterial products, muramyl dipeptide and endotoxin, on bone resorption in organ culture

The authors have compared two components of bacterial cell walls, muramyl dipeptide (MDP) and lipopolysaccharide (LPS), for their effects on bone resorption as measured by the release of previously incorporated super(45)Ca. The results indicate that chemically different products of bacterial cell wa...

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Bibliographic Details
Published in:Calcified tissue international 1982-12, Vol.34 (1), p.365-369
Main Authors: Raisz, Lawrence G., Alander, Cynthia, Eilon, Gabriel, Whitehead, S. Patricia, Nuki, Klaus
Format: Article
Language:English
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Summary:The authors have compared two components of bacterial cell walls, muramyl dipeptide (MDP) and lipopolysaccharide (LPS), for their effects on bone resorption as measured by the release of previously incorporated super(45)Ca. The results indicate that chemically different products of bacterial cell walls can stimulate bone resorption in vitro. These products may be distinguished by differences in dose response curve, serum inhibition, and collagenase release.
ISSN:0171-967X
1432-0827
DOI:10.1007/BF02411269