Evidence for multiple effects of vitamin D sub(3) on calcium absorption: Response of rachitic chicks, with or without partial vitamin D sub(3) repletion, to 1,25-dihydroxyvitamin D sub(3)

The effects of vitamin D sub(3) or 1,25-dihydroxyvitamin D sub(3) (1,25(OH) sub(2)D sub(3)), or both, on the relationship among calcium absorption, vitamin D-induced calcium-binding protein (CaBP), and phospholipid metabolism were examined. The observations support the proposal that at least two pha...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1982-01, Vol.79, p.7939-7943
Main Authors: Wasserman, R H, Brindak, ME, Meyer, SA, Fullmer, C S
Format: Article
Language:English
Online Access:Get full text
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Summary:The effects of vitamin D sub(3) or 1,25-dihydroxyvitamin D sub(3) (1,25(OH) sub(2)D sub(3)), or both, on the relationship among calcium absorption, vitamin D-induced calcium-binding protein (CaBP), and phospholipid metabolism were examined. The observations support the proposal that at least two phases of calcium absorption are influenced by 1,25(OH) sub(2)D sub(3) -- permeation of calcium across the brush border, and transfer of calcium through and out of the cell. The first phase responds more rapidly to 1,25(OH) sub(2)D sub(3) than does the second phase, correlates with changes in phospholipid metabolism, and might not be dependent on de novo protein synthesis. The second phase correlates with CaBP synthesis and therefore is dependent on protein synthesis. Either the first phase or the second phase can constitute the limiting step in calcium absorption.
ISSN:0027-8424