Tryptophan metabolism and immunogenetics in major depression: A role for interferon-γ gene

Highlight • This manuscript reports the association between the polymorphism of pro-inflammatory gene, the interferon-gamma gene, tryptophan degradation and depression.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2013-07, Vol.31, p.128-133
Main Authors: Myint, Aye Mu, Bondy, Brigitta, Baghai, Thomas C, Eser, Daniela, Nothdurfter, Caroline, Schüle, Cornelius, Zill, Peter, Müller, Norbert, Rupprecht, Rainer, Schwarz, Markus J
Format: Article
Language:English
Subjects:
Adult
Affective disorder
Aged
Allergy and Immunology
Depressive Disorder, Major - genetics
Depressive Disorder, Major - immunology
Depressive Disorder, Major - metabolism
Female
Genetics
Humans
Hydroxyindoleacetic Acid - metabolism
Immunogenetics
Interferon-gamma
Interferon-gamma - genetics
Interferon-gamma - metabolism
Kynurenine - genetics
Kynurenine - metabolism
Kynurenine pathway
Male
Middle Aged
Polymorphism, Genetic
Psychiatry
Serotonin - genetics
Serotonin - metabolism
SNP
Tryptophan - genetics
Tryptophan - metabolism
Tryptophan breakdown
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Description
Summary:Highlight • This manuscript reports the association between the polymorphism of pro-inflammatory gene, the interferon-gamma gene, tryptophan degradation and depression.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2013.04.003