Current metabolomics: Technological advances

Metabolomics, the global quantitative assessment of metabolites in a biological system, has played a pivotal role in various fields of science in the post-genomic era. Metabolites are the result of the interaction of the system's genome with its environment and are not merely the end product of...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2013-07, Vol.116 (1), p.9-16
Main Authors: Putri, Sastia P., Yamamoto, Shinya, Tsugawa, Hiroshi, Fukusaki, Eiichiro
Format: Article
Language:English
Subjects:
analytical methods
Biological and medical sciences
Biotechnology
cell physiology
Chemometrics
Chromatography, Liquid - methods
Chromatography, Supercritical Fluid - methods
Electrophoresis, Capillary - methods
Fundamental and applied biological sciences. Psychology
Gas Chromatography-Mass Spectrometry - methods
gene expression
genome
Magnetic Resonance Spectroscopy - methods
Mass spectrometry
Mass Spectrometry - methods
metabolites
Metabolome
Metabolomics
Metabolomics - methods
Multivariate analysis
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Summary:Metabolomics, the global quantitative assessment of metabolites in a biological system, has played a pivotal role in various fields of science in the post-genomic era. Metabolites are the result of the interaction of the system's genome with its environment and are not merely the end product of gene expression, but also form part of the regulatory system in an integrated manner. Therefore, metabolomics is often considered a powerful tool to provide an instantaneous snapshot of the physiology of a cell. The power of metabolomics lies on the acquisition of analytical data in which metabolites in a cellular system are quantified, and the extraction of the most meaningful elements of the data by using various data analysis tool. In this review, we discuss the latest development of analytical techniques and data analyses methods in metabolomics study.
ISSN:1389-1723
1347-4421
DOI:10.1016/j.jbiosc.2013.01.004