Impaired hypoxic ventilatory response following neonatal sustained and subsequent chronic intermittent hypoxia in rats

Highlights • Neonatal sustained hypoxia prior to CIH attenuated the acute HVR. • Neither sustained or CIH alone affected the HVR. • Sustained periods of reduced O2 saturation should be avoided in neonates vulnerable to apnea and CIH.

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2013-06, Vol.187 (2), p.167-175
Main Authors: Mayer, C.A, Ao, J, Di Fiore, J.M, Martin, R.J, MacFarlane, P.M
Format: Article
Language:English
Subjects:
Age Factors
Animals
Animals, Newborn
Breathing
Chronic intermittent hypoxia
Development
Female
Hypercapnia - physiopathology
Hypoxia - complications
Lung Diseases - etiology
Male
Medical Education
Oxygen Consumption
Plethysmography, Whole Body
Pregnancy
Pulmonary Gas Exchange
Pulmonary Ventilation - physiology
Pulmonary/Respiratory
Rats
Rats, Inbred Lew
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Description
Summary:Highlights • Neonatal sustained hypoxia prior to CIH attenuated the acute HVR. • Neither sustained or CIH alone affected the HVR. • Sustained periods of reduced O2 saturation should be avoided in neonates vulnerable to apnea and CIH.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2013.03.011