Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus)

The effect of the tumor promoter TPA and its inactive structural analogue 4-O-methyl-TPA on the induction of dorsal skin melanosis in the normal Syrian golden hamster and on the promotion of melanomas in DMBA-initiated animals was investigated. Both phenomena were observed in TPA-treated hamsters bu...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1982, Vol.103 (3), p.305-311
Main Authors: Goerttler, K, Hecker, E, Loehrke, H, Seip, H, Hesse, B, Schweitzer, J
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene
Animals
Cricetinae
Female
Melanocytes - drug effects
Melanoma - chemically induced
Mesocricetus
Phorbols - adverse effects
Skin Neoplasms - chemically induced
Tetradecanoylphorbol Acetate - adverse effects
Tetradecanoylphorbol Acetate - analogs & derivatives
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Summary:The effect of the tumor promoter TPA and its inactive structural analogue 4-O-methyl-TPA on the induction of dorsal skin melanosis in the normal Syrian golden hamster and on the promotion of melanomas in DMBA-initiated animals was investigated. Both phenomena were observed in TPA-treated hamsters but could not be detected after exposure of animals to 4-O-methyl-TPA. In contrast to results obtained with a variety of other laboratory animals, neither TPA nor 4-O-methyl-TPA were able to induce epidermal hyperplasia of hamster dorsal skin.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF00409706